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846-50-4

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Basic Information
CAS No.: 846-50-4
Name: TEMAZEPAM
Article Data: 22
Molecular Structure:
Molecular Structure of 846-50-4 (TEMAZEPAM)
Formula: C16H13 Cl N2 O2
Molecular Weight: 300.744
Synonyms: (RS)-Temazepam;(?à)-Temazepam;1-Methyl-3-hydroxy-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;3-Hydroxydiazepam;7-Chloro-1,3-dihydro-1-methyl-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-phenyl-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one;7-Chloro-3-hydroxy-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine; Crisonar; ER115; Euhypnos; Euipnos; Gelthix; K 3917; Levanxene; Levanxol; Methyloxazepam;N-Methyloxazepam; NSC 246303; Normison; Oxydiazepam; Perdorm; Planum; Racemictemazepam; Remestan; Restoril; Ro 5-5345; Ro 5-5354; Signopam; Temazepam;Tenox; Tenox (pharmaceutical); Wy 3917
Density: 1.34g/cm3
Melting Point: 119-121°C
Boiling Point: 549.9oC at 760 mmHg
Flash Point: 11oC
Hazard Symbols: Xn,T,F
Risk Codes: 22-39/23/24/25-23/24/25-11
Safety: Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: muscle weakness and changes in the structure or function of the salivary glands. A tranquilizer. When heated to decomposition it emits toxic fumes of Cl and NOx. See also DIAZEPAM.
PSA: 52.90000
LogP: 1.97280
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Chemistry

Product Name: Temazepam (CAS NO.846-50-4)


Molecular Formula: C16H13ClN2O2
Molecular Weight: 300.74g/mol
Mol File: 846-50-4.mol
Einecs: 212-688-1
Appearance: Crystalline Solid
Melting Point: 119-121°C
Boiling point: 549.9 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 286.4 °C
Density: 1.34 g/cm3
Surface Tension: 50.2 dyne/cm
Enthalpy of Vaporization: 87.32 kJ/mol
Vapour Pressure: 6.33E-13 mmHg at 25°C
XLogP3: 2.2
H-Bond Donor: 1
H-Bond Acceptor: 3
Product Categories: Heterocycles; Intermediates and Fine Chemicals; Metabolites and Impurities; Pharmaceuticals; Isotope Labeled Compounds

History

 Temazepam (CAS NO.846-50-4) was first synthesized in 1964, but it first came into use in 1969 when its ability to counter insomnia was realized.[5] By the late 1980s, temazepam was one of the most popular and widely prescribed hypnotics on the market and it became one of the most widely prescribed drugs.

Uses

Temazepam is a hypnotic agent. In sleep laboratory studies, temazepam significantly decreased the number of nightly awakenings but has the drawback of distorting the normal sleep pattern.
Temazepam is officially indicated for severe insomnia and other severe or disabling sleep disorders. The prescribing guidelines limit prescribing of hypnotics to two-to-four weeks due to concerns of tolerance and dependence.
The United States Air Force uses temazepam as one of the hypnotics approved as "no-go pills" to help aviators and special duty personnel sleep in support of mission readiness. "Ground tests" are required prior to authorization being issued to use the medication in an operational situation.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 3620mg/kg (3620mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981.
human TDLo oral 600ug/kg (0.6mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Human Psychopharmacology. Vol. 10, Pg. 449, 1995.
human TDLo oral 15430ug/kg/12 (15.43mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972.
man TDLo oral 429ug/kg (0.429mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: REGIDITY
Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985.
mouse LD50 intraperitoneal 85mg/kg (85mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 185, Pg. 135, 1970.
mouse LD50 oral 370mg/kg (370mg/kg) BEHAVIORAL: ANTICONVULSANT European Journal of Pharmacology. Vol. 4, Pg. 467, 1968.
rat LD50 intraperitoneal 600mg/kg (600mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981.
rat LD50 oral 2gm/kg (2000mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981.
women TDLo oral 600ug/kg (0.6mg/kg) BEHAVIORAL: EXCITEMENT Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: muscle weakness and changes in the structure or function of the salivary glands. A tranquilizer. When heated to decomposition it emits toxic fumes of Cl and NOx. See also DIAZEPAM.
Safety Information of Temazepam (CAS NO.846-50-4):
Hazard Codes: Xn,T,F
Risk Statements: 22-39/23/24/25-23/24/25-11 
11:  Highly Flammable
22:  Harmful if swallowed 
23:  Toxic by inhalation 
24:  Toxic in contact with skin 
25:  Toxic if swallowed 
39:  Danger of very serious irreversible effects
Safety Statements: 16-36/37-45
16:  Keep away from sources of ignition - No smoking
36:  Wear suitable protective clothing  
37:  Wear suitable gloves
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Specification

 Temazepam ,its CAS NO. is 846-50-4,the synonyms is 1,3-Dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one ; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl- ; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl- ; 3-Hydroxydiazepam ; 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one ; 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2h-4-benzodiazepin-2-one ; 7-Chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one