Detail of "84777-85-5"

CAS Number:
84777-85-5
Name:
2-Butenoic acid,4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-,(2R,4R,5S,6R)-2-[(1S,2R,3S)-3-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl]-2-hydroxy-1-methylbutyl]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-4-ylester
Molecular Structure:
Formula:
C48H71 N O14
Molecular Weight:
886.20
Synonyms:
2-Butenoicacid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-,(2R,4R,5S,6R)-2-[(1S,2R,3S)-3-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl]-2-hydroxy-1-methylbutyl]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-4-ylester (9CI); Concanamycin A, 23-O-de[4-O-(aminocarbonyl)-2,6-dideoxy-b-D-arabino-hexopyranosyl]-23-O-[4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-butenyl]-;2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, 2-[3-(11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)-2-hydroxy-1-methylbutyl]tetrahydro-2-hydroxy-5-methyl-6-(1-propenyl)-2H-pyran-4-ylester, [2R-[2R*[1S*[2R*,4R*,5S*,6R*(E)],2R*,3S*],3S*,4E,6E,9R*,10S*,11S*,12R*,13R*,14E,16Z]]-;Antibiotic AM 2604A; Virustomycin A
Safety:
Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Details

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Antibiotic AM-2604-A: Antibiotic AM-2604-A. Omura, Satoshi; Shimizu, Hideki (Kitasato Institute, Japan). U.S. US 4503152 A 5 Mar 1985, 11 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C12P017-16; C12P001-06; C12R001-465. NCL: 435118000. APPLICATION: US 83-459912 21 Jan 1983. PRIORITY: JP 82-6756 21 Jan 1982. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) Antibiotic AM2604A (I) [84777-85-5] is produced by fermn. with Streptomyces FERM-BP 234. Thus, a seed culture was inoculated into 70 L of medium contg. dextrin 2, glucose 0.2, soybean powder 1.5, yeast ext. 0.3, and CaCO3 0.3% and incubated at 27° for 67 h with stirring and aeration. The mycelium was extd. with a 60% Me2CO soln. The ext. was concd. and extd. with EtOAc. The EtOAc ext. was concd. from 10 L to 100 mL and allowed to stand overnight. The ppt. was chromatographed on silica gel. The fraction eluted by 4:1 benzene-Me2CO was concd. to 10 mL, 10 mL of Me2CO was added, and 650 mg I was obtained by crystn. I has little antibacterial activity but is active against viruses, fungi, coccidiosis in chickens, and Trichomonas in mice.

The structure of virustomycin A: The structure of virustomycin A. Omura, Satoshi; Imamura, Nobutaka; Hinotozawa, Kiyoizumi; Otoguro, Kazuhiko; Lukacs, Gabor; Faghih, Ramine; Tolmann, Richard; Arison, Byron H.; Smith, Jack L. (Sch. Pharm. Sci., Kitasato Univ., Tokyo 108, Japan). J. Antibiot., 36(12), 1783-6 (English) 1983. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 26 (Biomolecules and Their Synthetic Analogs) The mol. structure of virustomycin A (AM-2604A) was confirmed to be I from spectral data of I and some related compds. 84777-85-5 is just another one chemical used in this study. .