Reference

Prophylactic efficacy of maduramicin ammonium against chicken coccidia in a battery trial

Prophylactic efficacy of maduramicin ammonium against chicken coccidia in a battery trial. (I) Eimeria acervulina. Lee, Y. C.; Taniguchi, O.; Liu, Erich; Fang, B. H.; Weng, L. C. (Coll. Agric., Natl. Taiwan Univ., Taipei, Taiwan). Kuo Li T'ai-wan Ta Hsueh Nung Hsueh Yuan Yen Chiu Pao Kao, 25(2), 65-70 (Chinese) 1985. CODEN: KTNYA8. ISSN: 0077-5819. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Maduramicin ammonium [84878-61-5] at 5-7 ppm (in the diet) was more effective than salinomycin at 60 ppm or monensin at 100 ppm against coccidia in chicken infested orally with E. acervulina at 10 days of age; maduramicin at 6, but not at 5, ppm completely protected the birds against shedding oocysts in the feces.

Effect af a newly synthesized zinc salt in combined therapy with maduramycin on the antioxidant status Eimeria tenella infected broiler chickens

All Rights Reserved. Effect af a newly synthesized zinc salt in combined therapy with maduramycin on the antioxidant status Eimeria tenella infected broiler chickens. Koinarski, V.; Georgieva, N.; Gabrashanska, M. (Department of Veterinary Microbiology, Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, Trakia University, Stara 6000, Bulg.). Revue de Medecine Veterinaire (Toulouse, France), 157(5), 251-256 (English) 2006 Ecole Nationale Veterinaire de Toulouse. CODEN: RVMVAH. ISSN: 0035-1555. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of a newly synthesized Zn salt (2Gly.ZnCl2.2H2O) co-administered with an antioxidant drug, maduramycin, on the antioxidant status of broiler chickens infected with E. tenella were investigated through measurements of plasma MDA (malondialdehyde) concns. and of erythrocyte SOD (Superoxide Dismutase) and CAT (Catalase) activities. A total of 80 healthy Cobb 500 chickens were divided into 4 groups. In the group I, animals were not infected and not treated (neg. controls). In the 3 other groups, birds, aged of 13 days, were infected with E. tenella (8.104 oocysts) and were not treated (group II, pos. controls) or were orally treated for 9 days by only maduramycin (5 ppm) (group III) and by maduramycin (5 ppm) and Zn salt (2Gly.ZnCl2.2H2O) (0. 9054-89-1 and 84878-61-5 are cas registry numbers of chemicals which are used as reagents here.12g Zn2+/kg of food/day) (group IV). A markedly stunted growth and increase of FCR (food conversion ratio) were obsd. in pos. controls, whereas the 2 treatments partially reduced the adverse effects of the E. tenella infection on growth. Compared to the neg. controls, SOD activities were significantly reduced and CAT activities enhanced in all infected birds, and these changes were more intense in the 2 treated birds, particularly in birds receiving maduramycin and Zn salt. However, contrary to therapy with maduramycin alone, the cotreatment with Zn salt did not limit ROS formation: in this group, plasma MDA concns. remained significantly elevated and similar to values obsd. in pos. controls. These results confirm that the Eimeria tenella infection induces an oxidative stress in broiler chickens and that antioxidant therapy (maduramycin ± Zn salt) partially restored the growth, but they also suggest that Zn salt (2Gly.ZnCl2.2H2O) may present adverse effects on lipid peroxidn. .