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| CAS No.: | 849-55-8 |
|---|---|
| Name: | NYLIDRIN HYDROCHLORIDE |
| Article Data: | 2 |
| Molecular Structure: | |
|
|
|
| Formula: | C19H25NO2.ClH |
| Molecular Weight: | 335.874 |
| Synonyms: | Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-,hydrochloride (9CI);Benzyl alcohol, p-hydroxy-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-,hydrochloride (8CI);Nylidrin hydrochloride (6CI);Arlidin;Arlidinhydrochloride;Bufedon;Buphedrin;Buphenin hydrochloride;Bupheninehydrochloride;Dilatal;Dilatol;Dilatol hydrochloride;Dilatropon;Dilydrin;NSC 142004;Opino;Penitardon;Perdilatal;RHC 3432A;Rudilin;Rydrin;SKF 1700A;Suprifen Psb hydrochloride;Tocodilydrin;Tocodrin;Verina;p-Hydroxy-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzyl alcohol hydrochloride; |
| EINECS: | 212-701-0 |
| Melting Point: | 198-199℃ (decomposition) |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22 |
| Safety: | 36 |
| PSA: | 52.49000 |
| LogP: | 4.61790 |
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- 911112-05-55-Iodo-3-(trifluoromethyl)-2-pyridinamine
- 849-55-8
nylidrin hydrochloride
| Conditions | Yield |
|---|---|
| With 3% Pd/C; hydrogen In methanol at 20℃; | 95% |
- 35081-45-9
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone
- 22374-89-6
(RS)-1-methyl-3-phenylpropylamine
- 849-55-8
nylidrin hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: triethylamine / ethyl acetate / 5 h / Reflux 2: 3% Pd/C; hydrogen / methanol / 20 °C View Scheme |
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Chemistry
Product Name: Dilatol hydrochloride (CAS NO.849-55-8)
Molecular Formula: C19H26ClNO2
Molecular Weight: 335.87g/mol
Mol File: 849-55-8.mol
Einecs: 212-701-0
Boiling point: 476 °C at 760 mmHg
Flash Point: 127.3 °C
Enthalpy of Vaporization: 77.91 kJ/mol
Vapour Pressure: 7.23E-10 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 3
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 136mg/kg (136mg/kg) | Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973. | |
| mouse | LD50 | intravenous | 40mg/kg (40mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972. | |
| mouse | LD50 | oral | 250mg/kg (250mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972. | |
| rat | LD50 | intraperitoneal | 380mg/kg (380mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972. | |
| rat | LD50 | intravenous | 37400ug/kg (37.4mg/kg) | United States Patent Document. Vol. #3542870, | |
| rat | LD50 | oral | > 4800mg/kg (4800mg/kg) | Drugs in Japan Vol. 6, Pg. 538, 1982. |
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Safety Information of Dilatol hydrochloride (CAS NO.849-55-8):
Hazard Codes: Xn.gif){kind=small}
Risk Statements: 20/21/22
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
Specification
Dilatol hydrochloride ,its CAS NO. is 849-55-8,the synonyms is 1-p-Hydroxyphenyl-2-(1'-methyl-3'-phenylpropylamino)-1-propanolhydrochloride ; Arlidinhydrochloride ; Bupheninehydrochloride ; Dilatolhydrochloride ; Dilatyl ; p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-benzylalcohohyd ; p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzylalcoholhydro ; Suprifenpsbhydrochloride .