Reference

Pharmacokinetic properties of the new cephalosporin antibiotic HR 810 in animals

Pharmacokinetic properties of the new cephalosporin antibiotic HR 810 in animals. Klesel, N.; Seeger, K. (Abt. Chemother., Hoechst A.-G., Frankfurt/Main D-6230/80, Fed. Rep. Ger.). Infection (Munich), 11(6), 318-21 (English) 1983. CODEN: IFTNAL. ISSN: 0300-8126. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacokinetic profile of HR 810 (I) [84957-29-9] was investigated in mice, rats, rabbits, dogs, and monkeys. High blood serum levels were achieved following s.c., i.m. and i.v. injection, and half-lives ranged from 20 min in mice to 89 min in rabbits. The compd. was well distributed in the body and penetrated tissues and body fluids to a high degree. While large amts. of the antibiotic were recovered in the animals' urine, the recovery rate in bile was very low.

Chemotherapeutic properties of the new cephalosporin antibiotic HR810 in laboratory animals

Chemotherapeutic properties of the new cephalosporin antibiotic HR810 in laboratory animals. Klesel, N.; Limbert, M.; Schrinner, E.; Seeger, K.; Seibert, G.; Winkler, I. (Dep. Chemother., Hoechst A.-G., Frankfurt/Main D-6230/80, Fed. Rep. Ger.). Infection (Munich), 12(4), 286-92 (English) 1984. CODEN: IFTNAL. ISSN: 0300-8126. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 The chemotherapeutic properties of the new aminothiazolyl cephalosporin HR810 (I) [84957-29-9] were investigated in exptl. animals. Unlike other cephalosporins of the 3rd generation, HR810 had good activity against Staphylococcus aureus as well as some activity against enterococci. In murine protection tests with these strains, it was clearly superior to ceftazidime, cefotaxime, ceftriazone, cefoperazone, and latamoxef. The compds. most effective in protecting mice from infections caused by Enterobacteriaceae were HR810 and ceftriaxone, followed by ceftazidime, latamoxef, and cefotaxime; cefoperazone was less active. HR810 was less active against Pseudomonas aeruginosa than ceftazidime but was considerably more effective than the other cephalosporins tested. HR810 also proved effective against localized infections such as thigh lesions, as well as against meningoencephalitis in mice and pyelonephritis in rats. These results in lab. animals make HR810 a promising candidate for clin. studies.