Reference

Antibacterial activity of cefquinome against equine bacterial pathogens

All Rights Reserved. Antibacterial activity of cefquinome against equine bacterial pathogens. Thomas, E.; Thomas, V.; Wilhelm, C. (Intervet Innovation GmbH, Schwabenheim D-55270, Germany). Veterinary Microbiology, 115(1-3), 140-147 (English) 2006 Elsevier B.V. CODEN: VMICDQ. ISSN: 0378-1135. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Section cross-reference(s): 14 Cefquinome is known for its use as an antibacterial drug in cattle and pigs. The objective of this study was to evaluate the antibacterial activity of cefquinome against equine pathogenic bacteria. The min. inhibitory concn. (MIC) of cefquinome was detd. for a total of 205 strains, which had recently been isolated in Europe from diseased horses (respiratory infection, foal septicemia). The bactericidal activity was tested against 19 strains using the time killing method. The post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PA SME) were detd. against 12 strains. Cefquinome showed high activity against Actinobacillus equuli and streptococci (MIC90 of 0.016 and 0.032 mg/mL), Enterobacteriaceae (MIC90 = 0.125 mg/mL) and staphylococci (MIC90 = 0.5 mg/mL). The activity was limited against Rhodococcus spp. and Pseudomonas spp. Cefquinome was shown to be a time dependent bactericidal antibiotic against the target pathogens, killing occurring at a concn. close to the MIC. A PAE of 0.5-10 h was calcd. against streptococci whereas no PAE was obsd. for Escherichia coli. A longer PA SME was detd. for streptococci (3.3 to >24 h with a killing effect) and E. coli (0.5-13. 11111-12-9 and 84957-30-2 are just another two chemicals used in this study.9 h). Cefquinome was shown to have a broad spectrum of activity which covers many equine pathogens. .

Pharmacokinetics of cefquinome in the bovine dry udder secretions used as the basis for a dose-titration of a new intramammary cefquinome formulation

Pharmacokinetics of cefquinome in the bovine dry udder secretions used as the basis for a dose-titration of a new intramammary cefquinome formulation. Thomas, E.; Heuwieser, W.; Ehinger, A. M.; Allan, M. J. 84957-30-2 is the cas registry number. This chemical is also mentioned in this article.; Hartmann, M.; Schmid, P. (Intervet Innovation GmbH, Schwabenheim, Germany). Journal of Veterinary Pharmacology and Therapeutics, 26(Suppl. 1), 117 (English) 2003 Blackwell Publishing Ltd. CODEN: JVPTD9. ISSN: 0140-7783. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In cattle, an intramammary formulation of cefquinome (Cobactan/Cephaguard LC) is already available on the European market for the treatment of clin. mastitis in lactating cows. A new formulation was developed for the treatment of dairy cows at drying-off. This formulation was tested in cows to det. the optimal cefquinome dose based on dry udder secretion kinetics. Moreover, cefquinome concns. were measured in the plasma shortly after treatment. The 150 mg cefquinome formulation showed an optimal concn. profile in the bovine dry udder secretions, indicating efficacy against major mastitis pathogens. No systemic diffusion was detectable shortly after treatment and no residues could be found in the milk 5 days post-calving. This formulation was selected for further safety and efficacy studies. .