Detail of "85100-78-3"

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An assessment of ionic liquid mutagenicity using the Ames Test

All Rights Reserved. An assessment of ionic liquid mutagenicity using the Ames Test. Docherty, Kathryn M.; Hebbeler, Susanne Z.; Kulpa, Charles F., Jr. ( Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA). Green Chemistry, 8(6), 560-567 (English) 2006 Royal Society of Chemistry. CODEN: GRCHFJ. ISSN: 1463-9262. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Recent interest in ionic liqs. as green replacements for volatile org. solvents has led to an abundance of rapid toxicity testing to provide guidelines for safe designer engineering and synthesis. While toxicity tests have provided a wealth of information, no studies have investigated the mutagenicity of ionic liqs., which should be just as important for design guidelines. Here the authors present the results of the United States Environmental Protection Agency (US EPA) Ames Test for mutagenicity using Salmonella typhimurium strains TA98 and TA100 to ten ionic liqs. These include compds. with imidazolium, pyridinium and quaternary ammonium cations. Tests with these bacteria provide information on the ability of a chem. to cause frameshift and missense mutations, resp., and can be related to higher organism carcinogenicity. These test results indicated that none of the ten compds. tested met the US EPA criteria for mutagenicity. Two of the imidazolium cation ionic liqs. 85100-78-3 and 64-20-0 are just another two chemicals used in this study. indicated tendencies toward mutagenicity, but only at the highest doses. .