Detail of "85329-59-5"

Reference

Diterpenoids as analgesics

Diterpenoids as analgesics.Some chemicals with cas registry numbers like 79859-42-0 and 85329-59-5 are also used. Fujita, Eiichi; Fuji, Kaoru; Noide, Manabu; Takashima, Junko; Egawa, Mitsuo; Tobe, Akihiro (Mitsubishi Kasei Corp., Japan). Jpn. Kokai Tokkyo Koho JP 03264529 A2 25 Nov 1991 Heisei, 4 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: A61K031-365. ICA: C07D311-96. APPLICATION: JP 90-63838 14 Mar 1990. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 11 Analgesics contain diterpenoids I (R1, R2 = H, OH; R3 = H, acetoxy) as active ingredients. Rabdosia trichocarpa (dried leaves; 15 kg) was extd. with MeOH to give 3.2 kg ext., which was dissolved in EtOAc, evapd., and chromatographed on silica gel to give 16.2 g trichorabdal A, 5.7 g trichorabdal B, and 0.2 g trichorabdal C. Trichorabdal A at 125 mg/kg p.o. showed 33.60% writhing inhibition in mice in the HAOc writhing test, vs. 25.1% for aspirin. .