Detail of "85490-53-5"

CAS Number:
85490-53-5
Name:
Motilin (Canisfamiliaris) (9CI)
Molecular Structure:
Formula:
C120H194 N36 O34
Molecular Weight:
2685.05
Synonyms:
Motilin(pig), 7-L-histidine-8-L-serine-12-L-lysine-13-L-isoleucine-14-L-arginine-;249: PN: WO0069900 SEQID: 430 unclaimed sequence; 349: PN: US20090175821 SEQID:430 claimed protein; Canine motilin; L-Glutamine,L-phenylalanyl-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-histidyl-L-seryl-L-a-glutamyl-L-leucyl-L-glutaminyl-L-lysyl-L-isoleucyl-L-arginyl-L-a-glutamyl-L-lysyl-L-a-glutamyl-L-arginyl-L-asparaginyl-L-lysylglycyl-

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Rapid high-yield purification of canine intestinal motilin and its complete sequence determination: Rapid high-yield purification of canine intestinal motilin and its complete sequence determination. Reeve, J. R., Jr.; Ho, F. J.; Walsh, J. H.; Ben-Avram, C. M.; Shively, J. E. (Cent. Ulcer Res. Educ., Wadsworth Veterans Adm. Med. Cent., Los Angeles, CA 90073, USA). J. Chromatogr., 321(2), 421-32 (English) 1985. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Canine motilin [85490-53-5] was purified from small amts. of canine intestine in a form suitable for microsequence anal. The sequence detd. is: Phe-Val-Pro-Ile-Phe-Thr-His-Ser-Glu-Leu-Gln-Lys-Ile-Arg-Glu-Lys-Glu- Arg-Asn-Lys-Ile-Arg-Asn-Lys-Gly-Gln. Canine motilin differs from porcine motilin at 5 positions. The rapid, high-yield (24% overall yield) chromatog. microisolation techniques used for canine motilin should be suitable for the isolation of other basic peptides found in lower levels in tissue that is available only in limited amts.

Preparation of iodinated synthetic canine motilin for radioimmunoassay and radioreceptor assay: Preparation of iodinated synthetic canine motilin for radioimmunoassay and radioreceptor assay. Bielanski, Wladyslaw; Bormans, Vera; Peeters, Theo; Vantrappen, Gaston (Cent. Gastroenterol. Res., Univ. Leuven, Louvain B-3000, Belg.). Biomed. Res., 7(6), 445-8 (English) 1986. CODEN: BRESD5. ISSN: 0388-6107. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Synthetic canine motilin [85490-53-5] was labeled by the chloramine T method. Purifn. and sepn. of labeled from unlabeled hormone was carried out by gel-permeation chromatog. on Sephadex G-10 followed by ion exchange chromatog. on SP Sephadex C-25. The tracer was stored at -20° and was stable for at least 3 mo. Its specific radioactivity was 1655 mCi/nmol. Spontaneous motilin release in the fasting state in the dog was measured with 2 assay systems using either labeled canine or porcine motilin. The results from both assays correlated well and abs. values differed only slightly.