Reference

Effect of cyclovirobuxin D on the infarct size and metabolism of myocardium

Effect of cyclovirobuxin D on the infarct size and metabolism of myocardium. Rao, Manren; Liang, Manda; Liu, Guangyu; Liu, Tianpei (Dep. Pharmacol., Nanjing Med. Coll., Nanjing, Peop. Rep. China). Zhongcaoyao, 15(4), 161-3 (Chinese) 1984. CODEN: CTYAD8. ISSN: 0253-2670. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) I.p. injection of cyclovirobuxin D (I) [860-79-7] at 10 and 20 mg/kg markedly increased the antihypoxic time of mice with isoprenaline-induced cardiomyopathy in reduced atm. pressure (560 mmHg); the antihypoxic effect of I was dose-dependent. I.v. injection of I at 1 and 3 mg/kg dosages both markedly reduced the myocardial infarction induced by ligation of the left anterior descending artery in rabbits. The antimyocardial infarction and related functions of I were similar to those of propranolol, but the effects were less than those of propranolol; the myocardial lactic acid prodn. and K+ regulation effects of I in ligated animals were less than that of propranolol.

Buxine and buxine hydrochloride, production method and pharmaceutical preparation thereof

All Rights Reserved. Buxine and buxine hydrochloride, production method and pharmaceutical preparation thereof. Hang, Taijun; Zhang, Zhengxing; Liang, Bingwen; Yuan, Houliang; An, Dengkui; Liu, Jie; Fang, Taihui (Peop. Rep. China ). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1814616 A 9 Aug 2006,43pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. APPLICATION: CN 2010-57543 13 Mar 2006. 30276-35-8 and 860-79-7 are cas registry numbers. These chemicals are also mentioned in this article. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The title buxine (cyclovirobuxine D 60-95%; cyclobuxine D 1.0-30%; and cyclovirobuxine C 0.5-20%) is prepd. by grinding boxwood into powder; immersing with ammonia water; extg. with trichloromethane; vacuum distg. extractive soln. to obtain residue and recover trichloromethane;dissipating the residue with petroleum ether; extg. with dil. hydrochloric acid;decoloring extractive soln. with active carbon; adjusting pH to 12 with ammonia water; extg. with trichloromethane; vacuum distg. extractive soln. to remove most of solvent to ppt. solid; dissolving ppt. with proper amt. of trichloromethane; cooling and stranding to ppt. crystals; filtering; recrystg. from trichloromethane; and vacuum drying to obtain white to pale yellow product. Buxine hydrochloride is prepd. by charging excessive dry hydrochloric acid gas into trichloromethane contg. buxine; and post-treating to obtain final product. These compds. can be used for prepg. pharmaceutical prepns. such as tablet, capsule, syrups, pill, oral liq., etc. with the advantages of simple prepn. process and low cost. .