Reference

Nandrolone 17

Nandrolone 17.beta.-ester-containing drugs with anabolic activity. Van der Vies, Johannes (AKZO N. V., Neth.). Ger. Offen. DE 2638507 3 Mar 1977, 16 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-565. PRIORITY: NL 75-10104 27 Aug 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Oral compns.Several reagents with their cas registry numbers 1491-81-2 and 62541-10-0 are used here. with anabolic activity comprise .ltoreq.50% of a 17.beta.-ester (I) of nandrolone and a C9-18 aliph. carboxylic acid in a nonsteroidal lipid carrier. For example, 5g nandrolone was dissolved in 50 mL pentane and 5mL pyridine and esterified with 5 mL .alpha.-methylcapric acid to give 6.3 g nandrolone 17.beta.-.alpha.-methylcaprate [62516-28-3]. Soft gelatin capsules (0.12 mL) were filled with a sterile soln. of 83.33 g/L nandrolone 17.beta.-undecanoate (II) [862-89-5] in peanut oil so that each capsule contained 10 mg II. Tablets and hard gelation capsules contg. the nandrolone esters and lipid carriers were also prepd. .

Analysis of nandrolone esters in oily injections by reversed-phase high-performance liquid chromatography

Analysis of nandrolone esters in oily injections by reversed-phase high-performance liquid chromatography.Some chemicals with cas registry numbers like 862-89-5 and 100-52-7 are also used. Cavrini, V.; Di Pietra, A. M.; Raggi, M. A.; Sarti, R. (Ist. Chim. Farm. Tossicol., Bologna 40126, Italy). J. Pharm. Biomed. Anal., 5(1), 21-32 (English) 1987. CODEN: JPBADA. ISSN: 0731-7085. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A HPLC procedure is presented for the anal. of nandrolone esters [I, R = (CH2)2Ph; (CH2)8Me and (CH2)9Me] in com. oily injections. The anal. was carried out under isocratic, reversed-phase (RP8 column) conditions using a UV detector (240 nm). The system discriminates between nandrolone alc., a potential impurity, and its esters and permits the quantitation of trace benzaldehyde [100-52-7] derived from the oxidative degrdn. of benzyl alc. [100-51-6]. The proposed HPLC method was more specific and accurate than the pharmacopeial spectrophotometric assay procedure (isoniazid reagent). The interference of benzaldehyde with the isoniazid method was also investigated. .