CAS No.863-57-0,Glycine, N-[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]-,sodium salt (1:1) Suppliers,MSDS download

Detail of "863-57-0"

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CAS Number:

863-57-0

Name:

Glycine, N-[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]-,sodium salt (1:1)

Superlist Name:

Sodium glycocholate

Molecular Structure:

Formula:

C₂₆H₄₂NO₆Na

Molecular Weight:

487.60

Synonyms:

Glycine,N-[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]-,monosodium salt (9CI);Glycine, N-choloyl-, monosodium salt (8CI);Cholane,glycine deriv.;Glycocholic acid sodium salt;Monosodium glycocholate;NSC35609;Sodium cholylglycinate;

EINECS:

212-730-9

Melting Point:

210-215 °C

Appearance:

light green solid

Safety:

22-24/25 Details

Reference

Enhanced intestinal permeability to macromolecules: Enhanced intestinal permeability to macromolecules. I. Effect of monoolein-bile salts mixed micelles on the small intestinal absorption of heparin. Tokunaga, Yuji; Muranishi, Shozo; Sezaki, Hitoshi (Fac. Pharm. Sci., Kyoto Univ., Kyoto, Japan). J. Pharmacobio-Dyn., 1(1), 28-38 (English) 1978. CODEN: JOPHDQ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effect of monoolein-bile salts (Na glycocholate [863-57-0] and Na taurocholate [145-42-6]) micellar solns. on the intestinal absorption of heparin [9005-49-6] was investigated using the in situ closed loop of rats. These mixed micellar solns. enhanced the absorption of heparin and the mixed micellar soln. prepd. with distd. water facilitated the intestinal absorption of heparin more markedly than that prepd. with a phosphate buffer. This difference between mixed micellar distd. water soln. and mixed micellar buffer soln. was studied by ultrafiltration, pretreatment with the micellar and mixed micellar solns., and gut exsorption. Enhanced permeability is discussed from the standpoints of intraluminal interaction between the mixed micelles and heparin mols., and an alternation in the permeability of the mucosal membrane.

Injectable vitamin E solutions: Injectable vitamin E solutions. Ferro, Alberto; Steffen, Hans (Hoffmann-La Roche, F., und Co. A.-G., Switz.). Eur. Pat. Appl. EP 133258 A2 20 Feb 1985, 7 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, NL. (German). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: A61K031-355. ICS: A61K047-00. APPLICATION: EP 84-108606 20 Jul 1984. PRIORITY: CH 83-4029 22 Jul 1983; CH 84-2747 6 Jun 1984. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Aq. vitamin E [1406-18-4] injections contain phospholipids and bile acids or bile salts in a mol ratio of 0.2:1-0.9:1 and have 3100 g vitamin E/mol phospholipid. The solns. can contain 6-8% EtOH by wt. Thus, 1.8 mL 10% dl-a-tocopherol [10191-41-0] in MeOH, 0.76 mL 25% soybean lecithin in EtOH, and 3.9 mL 10% Na glycocholate [863-57-0] in MeOH were mixed, and the solvents were evapd. at 40°. The residue was stirred with 3.24 mL H2O to give a clear soln., which was sterilized by filtration, placed in ampuls, and autoclaved for 20 min.

Detail of "863-57-0"

Glycine, N-[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]-,sodium salt (1:1)

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Reference