Reference

Solid pharmaceutical preparations with high uniformity

Solid pharmaceutical preparations with high uniformity. Tateishi, Kimio; Ohnishi, Koetsu; Ohkubo, Hiroshi (Eisai Co., Ltd., Japan). Japan. Kokai JP 52136912 16 Nov 1977 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K009-20. APPLICATION: JP 76-50884 6 May 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Homogenous solid pharmaceuticals comprise isoprenoid-contg. active ingredients (which are solid at room temp.) and higher fatty acid esters having m.p. above that of the active ingredients. The active ingredients include isoprenoid compds. such as menatetrenone [863-61-6] and tocopheryl nicotinate [43119-47-7]. Thus, a tablet prepn. consists of carnauba wax 5, cryst. cellulose 200, lactose 400, hydroxypropylcellulose 30, corn starch 220, calcium carboxymethylcellulose 50, and menatetrenone 100 g.

High-speed liquid chromatography of isoprenoidquinones

High-speed liquid chromatography of isoprenoidquinones. II. Determination and photostability of phylloquinone, menaquinone-4 in injections. Yamano, Yoshiaki; Ikenoya, Satoru; Anze, Machiko; Ohmae, Masahiko; Kawabe, Kiyoshi (Anal. Res. Lab., Eisai Co., Ltd., Tokyo, Japan). Yakugaku Zasshi, 98(6), 774-81 (Japanese) 1978. CODEN: YKKZAJ. ISSN: 0031-6903. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22, 64 The photostability of phylloquinone (I) [84-80-0] and menaquinone-4 (II) [863-61-6] in infusions and injections was detd. by high-speed chromatog. on Permaphase ODS, using mobile phases dioxane-H2O () and MeOH-H2O () for I and II, resp. Both were stable when stored in dark. Phyllochromenol [34044-00-3] and menachromenol [65941-19-7] were the major decompn. products obtained by irradn. (350-500 nm).