Reference

Topical corticoid creams

Topical corticoid creams. Stindl, Wolfgang; Zimmermann, Ingfried; Reckers, Renate; Wendt, Hans; Arndt, Rainold (Schering A.-G.Several substances are used for example 86401-95-8 and 25122-46-7 which are their cas registry numbers. , Fed. Rep. Ger.). Ger. Offen. DE 3225848 A1 19 Jan 1984, 20 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-57; A61K031-56. APPLICATION: DE 82-3225848 7 Jul 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Topical creams contg. 0.005-2% by wt. of an antiinflammatory corticosteroid are prepd. by combining an oil-in-water emulsion with a water-in-oil emulsion and then adding the corticosteroid and any fragrance. An oil-in-water emulsion was prepd. by adding a soln. of di-Na EDTA 10, chloroquinaldol 10, H2O 300, and Carbopol 10 g to a melt of petrolatum 80, stearyl alc. 40, Myrj 30, and jojoba oil 50 g and stirring until the emulsion particle size is 20-70 m. A water-in-oil emulsion was prepd. by whipping 228 g H2O into a melt of petrolatum 220, Dehymuls 10, and white beeswax 10 g until the particle size was 20-70 m. The water-in-oil emulsion was added to the oil-in-water emulsion with vigorous mixing under a vacuum of 10 mm until a dispersion with a particle size of 10-50 m was obtained. The vacuum was removed and 5 g micronized (1-20 m) hydrocortisone acetate (I) [50-03-3] and 2 g of fragrance were dispersed in the emulsion. .

Acute irritant dermatitis: effect of short-term topical corticoid treatment

Acute irritant dermatitis: effect of short-term topical corticoid treatment. Berardesca, Enzo; Distante, Fernanda; Vignoli, Gian Piero; Robbiosi, Giacomo (Department of Dermatology, University of Pavia, Pavia, Italy). Current Problems in Dermatology, 22(Exogenous Dermatology), 86-90 (English) 1995 Karger. CODEN: APDEBX. ISSN: 0070-2064. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 4 Surfactants can induce skin irritation by removing stratum corneum lipids, extg. amino acids, proteins and natural moisturizing factors from corneocytes. Topical corticosteroids have been used for decades in the treatment of such disorders; however, more recently, the use of formulations contg. mixts. of stratum corneum lipids have been proposed. Indeed, it has been shown that EFAD animals show increased TEWL and barrier damage is normalized after application of topical linoleic acid [1, 2].Several substances with their cas registry numbers 86401-95-8 and 60-33-3 may be metioned in this study. In the present study, the authors have compared two corticosteroids of the last generation (budesonide 0.1% (BUD) and methylprednisolone aceponate 0.025% (MPA) in cream) vs. a product contg. omega-3 and omega-6 fatty acids with an approx. content of linoleic acid (LAC) near 5%. The purpose of this study was to assess in an exptl. model of irritation the usefulness of corticosteroids in treating irritated skin. .