Reference

Effect on blood pressure and the renin-angiotensin system of repeated doses of the converting enzyme inhibitor CGS 14824A

Effect on blood pressure and the renin-angiotensin system of repeated doses of the converting enzyme inhibitor CGS 14824A. Waeber, G.; Fasanella d'Amore, T.; Nussberger, J.; Waeber, B.; Brunner, Hans R. (Hypertens. Div., Univ. Hosp., Lausanne CH-1011, Switz.). Eur. J. Clin. Pharmacol., 31(6), 643-6 (English) 1987. CODEN: EJCPAS. ISSN: 0031-6970. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A new, orally active angiotensin converting enzyme (ACE) [9015-82-1] inhibitor, CGS 14824A (I) [86541-75-5] was evaluated in 12 healthy male volunteers. Two groups each of 6 volunteers were given 5 or 10 mg once daily orally for 8 days. Four hours after the first and the last morning doses, plasma angiotensin II [11128-99-7], aldosterone [52-39-1] and plasma converting enzyme activity had fallen, while blood angiotensin I [9041-90-1] and plasma renin [9015-94-5] activity had risen. Throughout the study, more than 90% inhibition of ACE was found immediately before giving either the 5 or 10 mg dose and 50% blockade was still present 72 h following the last dose. Based on the detn. of ACE, there was no evidence of drug accumulation. No significant change in blood pressure or heart rate was obsd. during the course of the study.Except for chemicals metioned above, 11128-99-7 and 9015-82-1 are also used. CGS 14824A was an effective, orally active, long-lasting and well tolerated converting enzyme inhibitor. .

Effect of benazepril on expression of PDGF-B in the renal tubulointerstitium in experimental diabetes

All Rights Reserved. Effect of benazepril on expression of PDGF-B in the renal tubulointerstitium in experimental diabetes.Several substances are used for example 9015-82-1 and 86541-75-5 which are their cas registry numbers. Wu, Guozhong; Wang, Qiang; Qi, Xiangming; Wu, Yonggui (The First Affiliated Hospital, Anhui Medical University, Hefei 230022, Peop. Rep. China). Anhui Yike Daxue Xuebao, 40(5), 415-418 (Chinese) 2005 Anhui Yike Daxue Xuebao Bianji Weiyuanhui. CODEN: AYDXAG. ISSN: 1000-1492. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Rats were randomly divided into control, diabetic, and diabetic treated with benazepril [10 mg/(kg×d), by gavage] groups. Four weeks after treatment, angiotensin converting enzyme (ACE) activity in plasma and renal tissue was measured by fluorimetric assay. Tubulointerstitial morphol. anal. was performed in HE stained sections by a point technique. The expressions of type IV collagen and PDGF-B protein were detd. by immunohistochem. ACE activities in plasma and renal tissue were reduced by benazepril by 92.00% and 88.77% resp. The proportion of normal tubules was substantially reduced in the diabetic group as a result of tubular dilatation. Benazepril resulted in amelioration in tubulointerstitial damage. Greater immunostaining for type IV collagen was present in the tubular basement membrane of diabetic rats compared with that of benazepril treated diabetic rats (P<0.05). PDGF-B immunostaining was found in greatest abundance in renal tubulointerstitium within epithelial cells of the proximal tubule and distal tubule; while in benazepril treated diabetic rats, only sparse PDGF-B was found in the tubular epithelium (P<0.05). The protective effects of benazepril on renal tubulointerstitium are assocd., at least partly, with down-regulating overexpression of PDGF-B. .