Detail of "86639-52-3"

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CAS Number:
86639-52-3
Name:
7-Ethyl-10-hydroxycamptothecin
Molecular Structure:
Formula:
C₂₂H₂₀N₂O₅
Molecular Weight:
392.40
Deleted CAS:
113015-38-6
Synonyms:
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione;1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline- 3,14(4H,12H)-dione,4,11-diethyl-4,9- dihydroxy-,(4S)-;Captothecin, 7-ethyl-10-hydroxy-;1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4,7-diethyl-4,10-dihydroxy-;7-Ethyl-10-hydroxy-camptothecin;7-Ethyl-10-Hydroxycamptothecin (SN-38);7-Ethyl-10-Hydroxy CPT;7-Ethyl-10-Hydroxy Camptothecine;7-Ethyl-10-hydroxycamptothecin (TECANS);7-Ethyl-10-hydroxycamptothecin (SN38);7-Ethyl-10- Hydroxycamptothecin;7-Ehthy-10-Hydroxycamptothecin;7-etyl-10-hydroxycamptothecin;7-Ethyl-10-hydroxy-camptothecine;7-ethyl-Hydroxycamptothecin;7-ethyl-Camptothecin;
Density:
1.51 g/cm³
Melting Point:
217 °C
Boiling Point:
810.3 °C at 760 mmHg
Flash Point:
443.8 °C
Appearance:
light-yellow solid

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Reference

A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38: A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38. Stubdal, Hilde; Perin, Noah; Lemmon, Marilyn; Holman, Patricia; Bauzon, Maxine; Potter, Philip M.In this study， 9016-18-6 and 86639-52-3 are also used.; Danks, Mary K.; Fattaey, Ali; Dubensky, Thomas; Johnson, Leisa (Onyx Pharmaceuticals, Richmond, CA 94806, USA). Cancer Research, 63(20), 6900-6908 (English) 2003 American Association for Cancer Research. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 3, 63 ONYX-015 has been used successfully in the clinic as a cancer therapeutic in combination with chemotherapy. The combination of ONYX-015 and chemotherapy appears to be more efficacious than either regimen alone. In this study, we try to enhance this combination by "arming" ONYX-015 with a therapeutic transgene, an approach more commonly used with nonreplicating viruses in the context of gene therapy. We chose the prodrug converting enzyme carboxylesterase (CE), which converts the camptothecin deriv. CPT-11 (irinotecan) to the much more potent chemotherapeutic SN-38. The transgene was introduced into three distinct positions in the E3 region of the adenovirus genome to allow either early or late expression during the virus life cycle. We demonstrate that each of these ONYX-015-based adenoviruses expresses an active CE enzyme that can efficiently convert CPT-11 to SN-38. Furthermore, the cytotoxicity of CE-expressing viruses, but not control viruses, is enhanced significantly in the presence of the prodrug. Finally, we demonstrate that we can achieve transgene expression and activity in vivo in a human tumor xenograft model, and that treatment with a CE-expressing virus in combination with CPT-11 enhances survival of tumor-bearing mice. These results indicate that the addn. of a prodrug converting enzyme may be a feasible approach to addnl. enhance the efficacy of replicating adenoviruses as cancer therapeutics. .

Biliary excretion mechanism of the camptothecin derivative irinotecan, CPT-11, and its metabolites in rats: Biliary excretion mechanism of the camptothecin derivative irinotecan, CPT-11, and its metabolites in rats.Several substances are used for example 97682-44-5 and 86639-52-3 which are their cas registry numbers. Chu, Xiaoyan; Kato, Yukio; Niinuma, Kayoko; Sugiyama, Yuichi (Dep. Pharmaceutics, Univ. Tokyo, Japan). Yakuri to Chiryo, 24(Suppl. 12), S/2105-S/2113 (Japanese) 1996 Raifu Saiensu Shuppan K.K. CODEN: YACHDS. ISSN: 0386-3603. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Biliary excretion mechanisms of the camptothecin deriv. irinotecan, CPT-11, and its metabolites SN 38 closed and open forms and SN 38-glucuronide closed and open forms were studied in vitro and in vivo in SD rats and canalicular multispecific org. anion transporter-deficient EHBR rats. The results are discussed with regard to the side effects from SN 38. .

Detail of "86639-52-3"

7-Ethyl-10-hydroxycamptothecin

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Reference