Reference

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

All Rights Reserved. Several substances are used for example 86672-58-4 and 7440-70-2 which are their cas registry numbers. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. [Erratum to document cited in CA]. Makara, Judit K.; Mor, Marco; Fegley, Darren; Szabo, Szilard I.; Kathuria, Satish; Astarita, Giuseppe; Duranti, Andrea; Tontini, Andrea; Tarzia, Giorgio; Rivara, Silvia; Freund, Tamas F.; Piomelli, Daniele ( Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hung.). Nature Neuroscience, 10(1), 134 (English) 2007 Nature Publishing Group. CODEN: NANEFN. ISSN: 1097-6256. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) This paper identified 6-methyl-2-p-tolylaminobenzo[d]oxazin-4-one(URB754;Specs) as a monoaclglycerol lipase (MGL) inhibitor that enhances hippocampal depolarization-induced suppression of inhibition (DSI). However, in subsequent tests of non-com. URB754, these results failed replication, suggesting that a bioactive impurity was present in the compd. material. This impurity was identified as bis(methylthio)mercurane (Supplementary Results online). Because this compd. interacts with multiple targets, another MGL inhibitor, methylarachidonyfluorophosphonate(MAFP), was tested which prolonged DSI (Figure 1), confirming that monoacylglycerol lipase contributes to the termination of DSI, as others have reported. Another generation of endocannabinoid metab. inhibitors is needed to test this hypothesis further. .