Detail of "869572-92-9"

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Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice

All Rights Reserved. Several substances are used for example 869572-92-9 which is its cas registry number. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Quenelle, Debra C.; Buller, R. M. L.; Parker, Scott; Keith, Kathy A.; Hruby, Dennis E.; Jordan, Robert; Kern, Earl R. (University of Alabama School of Medicine, Birmingham, AL, USA). Antimicrobial Agents and Chemotherapy, 51(2), 689-695 (English) 2007 American Society for Microbiology. CODEN: AMACCQ. ISSN: 0066-4804. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) ST-246 was evaluated for activity against cowpox virus (CV), vaccinia virus (VV), and ectromelia virus (ECTV) and had an in vitro 50% effective concn. (EC50) of 0.48 mM against CV, 0.05 mM against VV, and 0.07 mM against ECTV. The selectivity indexes were >208 and >2,000 for CV and VV, resp. The in vitro antiviral activity of ST-246 was significantly greater than that of cidofovir, which had an EC50 of 41.1 mM against CV and 29.2 mM against VV, with selectivity indexes of >7 and >10, resp. ST-246 administered once daily by oral gavage to mice infected intranasally with CV beginning 4 h or delayed until 72 h postinoculation was highly effective when given for a 14-day duration using 100, 30, or 10 mg/kg of body wt. When 100 mg/kg of ST-246 was administered to VV-infected mice, a duration of 5 days was sufficient to significantly reduce mortality even when treatment was delayed 24 h postinoculation. Viral replication in liver, spleen, and kidney, but not lung, of CV- or VV-infected mice was reduced by ST-246 compared to levels for vehicle-treated mice. When 100 mg/kg of ST-246 was given once daily to mice infected by the intranasal route with ECTV, treatment for 10 days prevented mortality even when treatment was delayed up to 72 h after viral inoculation. Viral replication in target organs of ECTV-infected mice was also reduced. .