Detail of "87-13-8"

CAS Number:
87-13-8
Name:
Propanedioic acid,2-(ethoxymethylene)-, 1,3-diethyl ester
Superlist Name:
Diethyl ethoxymethylenemalonate
Molecular Structure:
Formula:
C₁₀H₁₆O₅
Molecular Weight:
216.23
Deleted CAS:
69731-53-9
Synonyms:
Malonicacid, (ethoxymethylene)-, diethyl ester (6CI,7CI,8CI);Propanedioic acid,(ethoxymethylene)-, diethyl ester (9CI);(Ethoxymethylene)malonic acid diethylester;(Ethoxymethylene)propanedioic acid diethyl ester;2-(Ethoxymethylene)malonic acid diethyl ester;2-Ethoxy-1,1-bis(ethoxycarbonyl)ethene;Diethyl (ethoxymethylene)malonate;Diethyl (ethoxymethylene)propanedioate;Diethyl 2-(ethoxymethylene)malonate;Diethyl 2-(ethoxymethylidene)propanedioate;Diethyl[(ethyloxy)methylidene]propanedioate;Ethyl3-ethoxy-2-(ethoxymethylene)-3-oxopropanoate;NSC 62117;NSC 9068;
EINECS:
201-725-7
Density:
1.08 g/cm³
Melting Point:
-33 °C
Boiling Point:
280 °C at 760 mmHg
Flash Point:
107.6 °C
Solubility:
Insoluble in water
Appearance:
clear colourless to light yellow liquid
Hazard Symbols:
Xn
Risk Codes:
22-36/37/38-42/43
Safety:
26-36/37/39-27-24/25 Details
particular:
particular

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Reference

Study on the mechanism behind adjuvant action of diethylethoxymethylene malonate enhancing the rectal absorption of cefmetazole and lysozyme: Study on the mechanism behind adjuvant action of diethylethoxymethylene malonate enhancing the rectal absorption of cefmetazole and lysozyme. Nishihata, Toshiaki; Miyake, Masatoshi; Kamada, Akira (Fac. Pharm. Sci., Osaka Univ., Suita 565, Japan). J. Pharmacobio-Dyn., 7(9), 607-13 (English) 1984. CODEN: JOPHDQ. ISSN: 0386-846X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Diethylethoxymethylene malonate (DEEMM) [87-13-8] and diethyl maleate (DEM) [141-05-9] enhanced the rectal absorption of cefmetazole [56796-20-4] (a model of poorly absorbed water sol. drugs) in rats when studies were carried out using in vivo, in situ rectal loop and in vitro rectal everted sac method. Since an increase of cefmetazole transport was found when concn. of nonprotein sulfhydryls in rectal tissue was decreased by the presence of either DEEMM or DEM in the study using in vitro everted sac method and the enhancement of cefmetazole absorption by the coadministration of either DEEMM or DEM was suppressed by treatment with dimercaprol, membrane permeability of rectal tissue seems to be regulated by the concn. of nonprotein sulfhydryls in rectal tissue. On the other hand, it was also found that there were differences between the action of DEEMM and the action of DEM from the following two results: 1) enhancing action of DEEM was suppressed by the presence of calcium ion in microenema while action of DEM was not so much influenced, and 2) DEEMM enhanced the rectal absorption of lysozyme [9001-63-2] (a model of poorly absorbed macromol. drugs) in rabbits but DEM did not.

Rectal absorption of [Asu1,7]-eel calcitonin in rats: Rectal absorption of [Asu1,7]-eel calcitonin in rats. Myake, Masatoshi; Nishihata, Toshiaki; Nagano, Atuko; Kyobashi, Yasue; Kamada, Akira (Fac. Pharm. Sci., Osaka Univ., Suita 565, Japan). Chem. Pharm. Bull., 33(2), 740-5 (English) 1985. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) [Asu1,7]-eel calcitonin ([Asu1,7]-ECT) [60731-46-6] was not absorbed well from rat rectum. Although an unstirred layer may exist as a diffusion barrier for [Asu1,7]-ECT absorption, transport through the epithelial cell membrane is the limiting step for [Asu1,7]-ECT absorption. Coadministration of 0.33 M ethylacetoacetate phenylalanine enamine (PheEtAA) [90966-08-8], 0.17 M diethylethoxymethylenemalonate (DEEMM) [87-13-8], 0.6 M Na salicylate (SA) [54-21-7], or 0.05 M Na p-chloromercuriphenylsulfonate (p-CMP) [14110-97-5] increased the rectal [Asu1,7]-ECT absorption. In particular, PheEtAA and DEEMM resulted in >180 times greater area under the curve of [Asu1,7]-ECT compared to that when [Asu1,7]-ECT alone was administered rectally, and these 2 adjuvants were more effective than SA and p-CMP on the rectal [Asu1,7]-ECT absorption, though all 4 adjuvants coadministered at the above concn. with Na cefmetazole caused similar increases of rectal cefmetazole absorption.

Detail of "87-13-8"

Propanedioic acid,2-(ethoxymethylene)-, 1,3-diethyl ester

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Reference