Detail of "87-24-1"

Reference

Catalyst and method for polymerization of

Catalyst and method for polymerization of .alpha.-olefins. Toyota, Akinori; Minami, Syuji; Kashiwa, Norio (Mitsui Petrochemical Industries, Ltd., Japan). Ger. Offen. DE 2708588 8 Sep 1977, 35 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C08F010-00. PRIORITY: JP 76-21179 1 Mar 1976. DOCUMENT TYPE: Patent CA Section: 35 (Synthetic High Polymers) A mech. copulverized product obtained from a Mg halide, a carboxylic ester, and an alc. or phenol is allowed to interact with a liq. Ti halide in the absence of mech. pulverization, and the solid, halogen-contg. Ti product is mech. pulverized and combined with an org. Al compd. to give a polymn. catalyst for .alpha.-olefins. The catalyst gives a high yield of cryst. polyolefin with low fines content. Thus, a mixt. of 20 g anhyd. MgCl2, 5.74 g o-MeC6H4CO2Et [87-24-1], and 2.27 g o-MeC6H4OH (I) [95-48-7] was ball milled 24 h under N and stirred (10 g) with 100 mL TiCl4 2 h at 80.Chemical with cas number 64662-04-0 also plays role.degree. to give a solid which (0.027 g, 0.0225 mmol Ti) was combined with 3.75 mmol Et3Al [97-93-8] and 1.25 mmol p-MeC6H4CO2Et [94-08-6] in hexane and used to polymerize propylene, giving polymer (II) [9003-07-0] with apparent d. 0.31 g/mL and melt index 3.55, which was 95.3% cryst. and contained 12.6 wt.% particles of <105 .mu. diam.; yield was 25,000 g/Cl g. II with 94.4% crystallinity, d. 0.32, and melt index 5.08, and contg. 25% <105-.mu. particles, was obtained in 8600 g/Cl g yield when I was omitted. .

Spontaneous calcium release from sarcoplasmic reticulum

Spontaneous calcium release from sarcoplasmic reticulum. Effect of local anesthetics.Some chemicals with cas registry numbers like 1042-42-8 and 87-24-1 are also used. Volpe, Pompeo; Palade, Philip; Costello, Brian; Mitchell, Robert D.; Fleischer, Sidney (Dep. Mol. Biol., Vanderbilt Univ., Nashville, TN 37235, USA). J. Biol. Chem., 258(20), 12434-42 (English) 1983. CODEN: JBCHA3. ISSN: 0021-9258. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Local anesthetics inhibit spontaneous Ca2+ release from purified light sarcoplasmic reticulum in a time-dependent manner, varying considerably in the preincubation time required to exert maximal effect. At pH 7.0, hydrophilic and mostly charged local anesthetics, such as procaine [59-46-1], procainamide [51-06-9], and N-(2,6-dimethylphenylcarbamoylmethyl)triethylammonium bromide [24003-58-5], inhibit Ca2+ release only after long preincubations (hours), whereas more hydrophobic local anesthetics are effective after only a short incubation (minutes) with sarcoplasmic reticulum. The more hydrophobic anesthetics take somewhat longer to reach equil., as studied by inhibition of unidirectional Ca2+ efflux, and there is a direct relation between hydrophobic partition coeff. and half-time to reach equil. Agents known to inhibit permeability pathways for monovalent cations, i.e., K+ channel blockers or anion blockers, do not inhibit spontaneous Ca2+ release. Carbonylcyanide m-fluorophenylhydrazone, a protonophore, and gramicidin D, a monovalent cation ionophore, have no effect on Ca2+ release whether local anesthetics are present or not, while the Ca2+ ionophore A23187 relieves the inhibition of Ca2+ release by local anesthetics. Ruthenium red does not inhibit spontaneous Ca2+ release. Apparently, the binding site(s) for local anesthetics is located on the inner face of the sarcoplasmic reticulum membrane, and local anesthetics interact directly with a Ca2+ channel rather than with other permeability pathways which might indirectly influence Ca2+ channel gating. .