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| CAS No.: | 87-59-2 |
|---|---|
| Name: | 2,3-Dimethylaniline |
| Article Data: | 59 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H11N |
| Molecular Weight: | 121.182 |
| Synonyms: | 2,3-Xylidine(8CI);2,3-Xylidine;2,3-Dimethylbenzenamine;2,3-Xylylamine;3-Amino-o-xylene;o-Xylidine; |
| EINECS: | 201-755-0 |
| Density: | 0.975 g/cm3 |
| Melting Point: | 2.5 °C(lit.) |
| Boiling Point: | 221.9 °C at 760 mmHg |
| Flash Point: | 96.1 °C |
| Solubility: | 30 g/L (20 °C) in water |
| Appearance: | brown liquid |
| Hazard Symbols: |
 T, N
|
| Risk Codes: | 23/24/25-33-51/53 |
| Safety: | 28-36/37-45-61-28A |
| Transport Information: | UN 1711 6.1/PG 2 |
| PSA: | 26.02000 |
| LogP: | 2.46680 |
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1-tert-butyl-N-(2,3-dimethylphenyl)-1,1-dimethylsilanamine
- 87-59-2
2,3-Dimethylaniline
| Conditions | Yield |
|---|---|
| With silica gel In ethanol; water at 20℃; for 2h; | 100% |
| Conditions | Yield |
|---|---|
| With sodium sulfide; tetrabutylammomium bromide In water; toluene at 80℃; for 0.75h; Zinin reduction; | 96.8% |
| Stage #1: 2,3-dimethylnitrobenzene In water at 20℃; for 0.05h; Green chemistry; Stage #2: With glycerol In water at 20℃; for 1.5h; Green chemistry; | 95% |
| With sodium tetrahydroborate In water at 60 - 70℃; for 0.133333h; Green chemistry; | 95% |
- 18595-13-6
2-amino-6-methylbenzoic acid methyl ester
- 87-59-2
2,3-Dimethylaniline
| Conditions | Yield |
|---|---|
| With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene for 3h; Heating; | 75% |
| Conditions | Yield |
|---|---|
| With tris-(2-chloro-ethyl)-amine; trifluorormethanesulfonic acid; trifluoroacetic acid In chloroform at 25℃; for 1h; | A 44% B 30% |
| bei der Nitrierung und Hydrierung des Reaktionsprodukts in Gegenwart von Nickel bei 180-190grad; | |
| With xenon difluoride; trimethylsilyl isocyanate; trifluorormethanesulfonic acid In dichloromethane at -78℃; |
- 619-04-5
3,4-dimethylbenzoic acid
A
- 95-65-8
3,4-Dimethylphenol
B
- 95-64-7
4-amino-o-xylene
C
- 87-59-2
2,3-Dimethylaniline
| Conditions | Yield |
|---|---|
| With ammonia; water; copper(II) oxide at 220℃; for 0.5h; | A 3.5% B 43.1% C 0.9% |
- 87-59-2
2,3-Dimethylaniline
| Conditions | Yield |
|---|---|
| With sodium amalgam |
- 593-53-3
Methyl fluoride
- 108-44-1
1-amino-3-methylbenzene
A
- 95-78-3
2,5-Dimethylaniline
B
- 95-64-7
4-amino-o-xylene
C
- 87-59-2
2,3-Dimethylaniline
| Conditions | Yield |
|---|---|
| With oxygen In gaseous matrix at 80℃; Irradiation; | A 29 % Spectr. B 25 % Spectr. C 46 % Spectr. |
| Conditions | Yield |
|---|---|
| In dichloromethane at 21.9℃; Equilibrium constant; |
| Conditions | Yield |
|---|---|
| In dichloromethane at 21.9℃; Equilibrium constant; |
- 87-59-2
2,3-Dimethylaniline
| Conditions | Yield |
|---|---|
| With iron; acetic acid |
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Chemistry
Chemical Name: 2,3-Dimethylaniline
IUPAC NAME: 2,3-Dimethylaniline
CAS No.: 87-59-2
EINECS: 201-755-0
RTECS: ZE8750000
RTECS Class: Mutagen
EC Class: toxic, dangerous for the environment
Molecular Formula: C8H11N
Molecular Weight: 121.18 g/mol
Polar Surface Area: 26.02 Å2
Index of Refraction: 1.559
Molar Refractivity: 40.13 cm3
Molar Volume: 124.2 cm3
Surface Tension: 37.9 dyne/cm
Density: 0.975 g/cm3
Flash Point: 96.1 °C
Enthalpy of Vaporization: 45.84 kJ/mol
Boiling Point: 221.9 °C at 760 mmHg Vapour Pressure: 0.105 mmHg at 25°C
2,3-Xylidine (87-59-2) is stable under normal temperatures and pressures.but incompatible with Strong oxidizing agents, acids, acid chlorides, halogens, acid anhydrides, hypochlorite, chloroformates.The pale yellow liquid with special smell is slightly soluble in water and the water solubility is equal to 30 g/L (20 °C), it is miscible in ethanol, ethyl ether.
Following is the structure of 2,3-Xylidine (CAS NO.87-59-2):
The chemical synonymous of 2,3-Xylidine (CAS NO.87-59-2) are 2,3-Dimethylaniline ; 2,3-Dimethylbenzenamine ; 2,3-Dimethylphenylamine ; 2,3-Xylylamine ; 3-Amino-o-xylene ; 4-12-00-02497 (Beilstein Handbook Reference) ; BRN 0742174 ; Benzenamine, 2,3-dimethyl- ; Benzene, 1-amino-2,3-dimethyl- ; CCRIS 4739 ; EINECS 201-755-0 ; HSDB 2091 ; o-Xylidine ; ortho-Xylidine
Uses
2,3-Xylidine (CAS NO.87-59-2) is mainly used in organic synthesis and used an the main raw material of mefenamic acid.
Production
Product Categories about 2,3-Xylidine (CAS NO.87-59-2) are Intermediates of Dyes and Pigments;Intermediates.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 836mg/kg (836mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Proceedings of the Western Pharmacology Society. Vol. 6, Pg. 11, 1963. |
| rat | LD50 | oral | 933mg/kg (933mg/kg) | National Technical Information Service. Vol. PB214-270, |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes: 
T,
N
Risk Statements: 23/24/25-33-51/53
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R33: Danger of cumulative effects.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 28-36/37-45-61
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 1711 6.1/PG 2
WGK Germany: 2
RTECS: ZE8750000
HazardClass: 6.1
PackingGroup: II
HS Code: 29214910
A poison. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also XYLIDINE; 2,4-XYLIDINE; 2,5-XYLIDINE; 2,6-XYLIDINE; 3,4-XYLIDINE; 3,5-XYLIDINE; 2,4-XYLIDINE HYDROCHLORIDE; 2,5-XYLIDINE HYDROCHLORIDE.
Standards and Recommendations
DFG MAK: (all isomers except 2,4-xylidene) 5 ppm (25 mg/m3)
Specification
1. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
3. Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
4. Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam. Do NOT get water inside containers.
5. Reactivity Profile 2,3-Dimethylaniline reacts with strong oxidizing agents and hypochlorite bleaches . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.