Detail of "87-87-6"

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CAS Number:
87-87-6
Name:
1,4-Benzenediol,2,3,5,6-tetrachloro-
Molecular Structure:
Formula:
C6H2 Cl4 O2
Molecular Weight:
247.88
Synonyms:
Hydroquinone,tetrachloro- (6CI,7CI,8CI); 2,3,5,6-Tetrachloro-1,4-benzenediol;2,3,5,6-Tetrachloro-1,4-dihydroxybenzene; 2,3,5,6-Tetrachlorohydroquinone;Dihydro-p-chloranil; NSC 100888; NSC 4858; Nordrosophilin A;Perchlorohydroquinone; Tetrachloro-1,4-benzenediol;Tetrachloro-1,4-hydroquinone; Tetrachloro-p-benzohydroquinone;Tetrachloro-p-hydroquinone; Tetrachlorobenzoquinol
EINECS:
201-779-1
Density:
1.848 g/cm³
Melting Point:
238-240ºC
Boiling Point:
286.2 ºC
Flash Point:
126.9ºC
Appearance:
tan-coloured or yellowish powder
Hazard Symbols:
Xn
Risk Codes:
22-41
Safety:
Poison by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻. Details

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Tetrachlorohydroquinone

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TETRACHLOROHYDROQUINONE

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Address:2-8, Nihonbashi Honcho 3-chome,Chuo-ku, Tokyo, 103-0023, Japan

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DNA-damaging properties and cytotoxicity in human fibroblasts of tetrachlorohydroquinone, a pentachlorophenol metabolite: DNA-damaging properties and cytotoxicity in human fibroblasts of tetrachlorohydroquinone, a pentachlorophenol metabolite. Witte, I.; Juhl, U.; Butte, W. (Fachbereich Biol., Univ. Oldenburg, Oldenburg 2900, Fed. Rep. Ger.). Mutat. Res., 145(1-2), 71-5 (English) 1985. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The DNA-damaging potential of PCP [87-86-5] and its metabolite tetrachlorohydroquinone (TCH)(I) [87-87-6] was investigated. TCH bound covalently to calf-thymus DNA and caused single-strand breaks in PM2 DNA. No DNA-damaging effects were obsd. for PCP. Exposure of human fibroblasts to PCP and TCH showed that TCH is more toxic, when colony-forming ability after exposure to the agent is used as a measure of toxicity. In the evaluation of the mutagenic and carcinogenic potential of PCP the metabolite TCH should be taken into consideration.

Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene: Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene. Van Ommen, B.; Van Bladeren, P. J.; Temmink, J. H. M.; Mueller, F. (Dep. Toxicol., Agric. Univ., Wageningen 6703 BC, Neth.). Biochem. Biophys. Res. Commun., 126(1), 25-32 (English) 1985. CODEN: BBRCA9. ISSN: 0006-291X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) On incubation of 14C-labeled hexachlorobenzene (I) [118-74-1] with rat liver microsomes, the major product (80-90%) was pentachlorophenol [87-86-5]. The only other detectable metabolite, tetrachlorohydroquinone [87-87-6] (4-15%), was presumably formed from pentachlorophenol. A considerable amt. of radioactivity (5-10% of the amt. of extd. metabolites) was covalently bound to protein. Microsomes derived from male I-induced rats gave by far the highest conversion (~1% of substrate). Microsomes from female I-induced rats were 3 times less efficient. Microsomes from untreated and 3-methylcholanthrene-treated animals gave <5% of the amt. of pentachlorophenol formed by microsome from I-induced male rats, whereas phenobarbital and Aroclor 1254-induction resulted in formation of 51% and 34%, resp.