Detail of "870-93-9"

Reference

Anti-inflammatory drugs in experimental atherosclerosis

Anti-inflammatory drugs in experimental atherosclerosis. Part 3. Evaluation of the atherogenicity of homocystine in rabbits. Makheja, A. N.; Bombard, A. T.; Randazzo, R. L.; Bailey, J. M. (Dep. Biochem., George Washington Univ. Sch. Med., Washington, D. C., USA). Atherosclerosis (Shannon, Irel.), 29(1), 105-12 (English) 1978. CODEN: ATHSBL. ISSN: 0021-9150. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 1 Dietary administration of DL-homocysteine thiolactone-HCl [6038-19-3], DL-homocystine [870-93-9], or DL-homocysteic acid [504-33-6] to rabbits for 12 wk only slightly increased plasma levels of homocystine, did not affect serum cholesterol [57-88-5] levels, did not alter the pattern of collagen-induced platelet aggregation, and induced no atherosclerotic plaque formation. The absence of pathol. effects was consistent with the rapid clearance of i.v. injected homocystine from rabbit plasma. Thus, the rabbit is not an acceptable exptl. model for study of the thromboatherogenic effects of homocystine reported for humans and some other animals.

Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids

Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids. Hilton, Mary A.; Hoffman, Jerald L.; Sparks, Margaret K. (Sch. Med., Univ. Louisville, Louisville, KY 40292, USA). Cancer Res., 43(11), 5210-16 (English) 1983. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The survival time of DBA/2 mice bearing methionine [63-68-3]-dependent L1210 or L5178Y leukemia cells was increased by i.p. administration of LDs of methotrexate [59-05-2] (5 daily doses of 25 mg/kg) followed by rescue with 5-methyltetrahydrofolate [134-35-0] (5 daily doses of 20 mg/kg).Several substances with their cas registry numbers 979-92-0 and 29908-03-0 may be metioned in this study. The mice were maintained on a semipurified choline and cyst(e)ine-free diet contg. 0.32% L-methionine. The survival time of the treated animals bearing L5178Y cells, but not those bearing L1210 cells, was further increased by substitution of 0.86% DL-homocystine [870-93-9] for the methionine in the diet. The effects of both diets in mice treated with methotrexate and 5-methyltetrahydrofolate, singly and in combination, were examd. on the concns. of S-adenosylmethionine [29908-03-0] and S-adenosylhomocysteine [979-92-0] in the liver, a tissue highly active in the metab. of these amino acids. The substitution of homocystine for methionine in the diet of untreated animals led to an increase in S-adenosylhomocysteine and decrease in S-adenosylmethionine in the liver which was not further altered by methotrexate. .