Detail of "87051-43-2"

Reference

Role of dopaminergic and serotonergic neuronal systems in the prefrontal cortex of rats in phencyclidine-induced behaviors

Role of dopaminergic and serotonergic neuronal systems in the prefrontal cortex of rats in phencyclidine-induced behaviors. Yamaguchi, Kazumasa; Nabeshima, Toshitaka; Kameyama, Tsutomu (Fac. Pharm. Sci., Meijo Univ., Nagoya 468, Japan). J. Pharmacobio-Dyn., 9(12), 987-96 (English) 1986. CODEN: JOPHDQ. ISSN: 0386-846X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The action sites of phencyclidine (PCP) [77-10-1] involved in the development of behaviors such as head-weaving, immobility, turning and backpedalling in relation to dopaminergic and serotonergic neuronal functions were studied. Injection of PCP into the caudate nucleus or prefrontal cortex dose-dependently produced head-weaving, although the injection of PCP into the nucleus accumbens failed to produce head-weaving. The intensity of head-weaving induced by injection of PCP into the prefrontal cortex was relatively high when compared to that induced by injection of PCP into the caudate nucleus or lateral ventricle. Pretreatment with p-chlorophenylalanine [1991-78-2], (300 mg/kg), a serotonin (5-HT) synthesis inhibitor, attenuated head-weaving induced by injection of PCP into the prefrontal cortex. Injection of PCP (50-100 mg) into the prefrontal cortex also produced immobility for 5 min post-injection. Rats pretreated with pimozide [2062-78-4] (1 mg/kg), a dopamine (DA) antagonist, also produced immobility after the injection of PCP into the prefrontal cortex and this effect was attenuated by pretreatment with ritanserin [87051-43-2], a 5-HT2 receptor antagonist. On the other hand, pretreatment with methamphetamine [537-46-2] attenuated PCP (5 and 7.5 mg/kg)-induced turning and backpedalling but not head-weaving. 537-46-2 which is the cas registry number of some chemical is mentioned. Pretreatment with large doses of apomorphine [58-00-4], a DA agonist, also greatly attenuated PCP (7.5 mg/kg)-induced behaviors, i.e. head-weaving, turning and backpedalling. These effects of DA agonists were prevented by haloperidol [52-86-8] (0.25 mg/kg), a DA antagonist. These results suggest that PCP-induced turning and backpedalling may be mediated by reducing dopaminergic transmission, although PCP-induced head-weaving and immobility may be produced by increasing serotonergic transmission in the prefrontal cortex. .

Atypical antipsychotic agents

Atypical antipsychotic agents. Vinick, Fredric J.; Kozlowski, Michael R. (Pfizer Cent. Res., Groton, CT 06340, USA).Some commonly used reagents like 86487-64-1 and 75859-04-0 are used in this experiment. Annu. Rep. Med. Chem., 21, 1-9 (English) 1986. CODEN: ARMCBI. ISSN: 0065-7743. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review with 161 refs. Atypical antipsychotics have decreased ability to produce extrapyridimal side effects. Properties of clozapine [5786-21-0], fluperlapine [67121-76-0], rimcazole [75859-04-0], ritanserin [87051-43-2], setoperone [86487-64-1] and some putative atypical antipsychotics are discussed. .