Detail of "87096-84-2"

Reference

Three tachykinins in mammalian brain

Three tachykinins in mammalian brain. Harmar, Anthony J. (Dep. Pharmacol., Univ. Edinburgh, Edinburgh EH8 9JZ, UK). Trends NeuroSci. (Pers. Ed.), 7(3), 57-60 (English) 1984. CODEN: TNSCDR. ISSN: 0166-2236. DOCUMENT TYPE: Journal; General Review CA Section: 2 (Mammalian Hormones) A review, with 16 refs., on substance P [33507-63-0], substance K [86933-74-6], neuromedin K [87096-84-2], and preprotachykinins.

Effect of neuromedin B on gut hormone secretion in the rat

Effect of neuromedin B on gut hormone secretion in the rat. Namba, Mitsuyoshi; Ghatei, Mohammad A.; Adrian, Thomas E.; Bacarese-Hamilton, Adolfo J.; Mulderry, Peter K.; Bloom, Stephen R. (R. Postgrad. Med. Sch., Hammersmith Hosp., London W12 OHS, UK). Biomed. Res., 5(3), 229-33 (English) 1984. CODEN: BRESD5. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Neuromedin B [87096-84-2] is a novel decapeptide which has recently been isolated from porcine spinal cord and shows striking sequence homol. with bombesin-like peptides at the C-terminal region. The effect of synthetic neuromedin B on the secretion of gastrointestinal and pancreatic regulatory peptides was compared with bombesin [31362-50-2] in the rat. Insulin [9004-10-8], glucagon [9007-92-5], enteroglucagon [62340-29-8], gastrin [9002-76-0], cholecystokinin (CCK) [9011-97-6], and bombesin were measured in plasma by RIAs. Neuromedin B (1.0 nmol) stimulated insulin, enteroglucagon, gastrin, and CCK release, similar in pattern but slightly less potent than that of bombesin (1.0 nmol). Neuromedin B had no effect on plasma concns. of glucagon and bombesin. Neuromedin B could thus be one of the neural factors which plays a regulatory role in the control of the endocrine pancreas and gastrointestinal tract.