Detail of "87138-77-0"

Reference

3-Chloro-1,3,5-pregnatriene derivatives with glucocorticoid activity

3-Chloro-1,3,5-pregnatriene derivatives with glucocorticoid activity. Aranyi, P.; Naray, A.; Ninh, N. V.; Fekete, G.; Toth, J.; Horvath, I. (Med. Sch., Semmelweis Univ., Budapest H-1444, Hung.). Steroids, 42(4), 409-15 (English) 1983. CODEN: STEDAM. ISSN: 0039-128X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Novel synthetic glucocorticoid analogs (3-chlorotriamcinolone acetonide [87138-72-5], 3-chloro-6-bromotriamcinolone acetonide [87126-48-5], and 3-chloro-6-fluocinolone acetonide [87138-77-0]) were tested for receptor binding and glucocorticoid activity. They were of unusual structure, insofar as they had a 3-chloro rather than a 3-oxo function. The 3-chloro analogs of fluorinated glucocorticoids formed extremely stable complexes with the rat liver glucocorticoid receptor. The 3-chloro deriv. of fluocinolone acetonide also had in vivo glucocorticoid activity. It induced tyrosine aminotransferase in the liver and repressed thymidine kinase in the thymus very effectively. Evidently, the 3-chloro analogs retain glucocorticoid activity as well as the ability to bind to the glucocorticoid receptor protein.