CAS No.87266-37-3,1H-Imidazole-1-acetic acid hydrochloride Suppliers

Detail of "87266-37-3"

CAS Number:

87266-37-3

Name:

1H-Imidazole-1-acetic acid hydrochloride

Molecular Structure:

Formula:

C₅H₆N₂O₂^.HCl

Molecular Weight:

162.57

Synonyms:

Imidazol-1-ylacetic acid hydrochloride;1H-Imidazolyl-Acetic Acid HCl;1H-Imidazole-1-Acetic Acid HCl;1H-Imidazole-1-acetic acid monohydrochloride;Imidazol-1-yl-acetic acid hydrochloride;

Melting Point:

193-195 °C

Boiling Point:

452.9 °C at 760 mmHg

Flash Point:

227.7 °C

Appearance:

White crystalline powder

Reference

Synthesis of zoledronic acid: All Rights Reserved. Synthesis of zoledronic acid.In this study， 87266-37-3 and 118072-93-8 are also used. Jiang, Ye; Zhang, Xiaoqing; Xu, Zhiru (Institute of Pharmacy, Hebei Medical University, Shijiazhuang 050017, Peop. Rep. China). Huaxi Yaoxue Zazhi, 20(1), 29-30 (Chinese) 2005 Huaxi Yike Daxue Yaoxueyuan. CODEN: HYZAE2. ISSN: 1006-0103. DOCUMENT TYPE: Journal CA Section: 29 (Organometallic and Organometalloidal Compounds) Zoledronic acid was synthesized from imidazol-1-yl-acetic acid HCl in concd. H3PO4 solvent with anhyd. alc. as crystn. solvent. The method avoided the use of some poisonous solvent. The yield was increased from 40.0% to 58.8%. The structure of zoledronic acid was confirmed by 1HNMR and MS. .

Processes for preparation of crystal forms of zoledronic acid and zoledronate sodium salts: Processes for preparation of crystal forms of zoledronic acid and zoledronate sodium salts. Aronhime, Judith; Lifshitz-Liron, Revital (Teva Pharmaceutical Industries, Ltd.; Teva Pharmaceuticals USA, Inc., Israel). PCT Int. Appl. WO 2005005447 A2 20 Jan 2005, 115 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07F009-02. APPLICATION: WO 2004-US21626 6 Jul 2004. PRIORITY: US 2003-PV484876 3 Jul 2003. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 29, 75 The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salts, processes for making the polymorphs and amorphous zoledronate sodium salt and pharmaceutical compns. contg. the polymorphs and amorphous zoledronate sodium salt. For example, zoledronic acid crystal Form I was prepd. by a phosphorylation reaction of 1-imidazoleacetic acid in the presence of phosphorous acid and phosphorus oxychloride in silicon oil as a diluent.Except for chemicals metioned above, 87266-37-3 and 827573-23-9 are also used. .

Detail of "87266-37-3"

1H-Imidazole-1-acetic acid hydrochloride

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CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

CAS No.87266-37-3 1H-Imidazole-1-acetic acid hydrochloride

Reference