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Detail of "87333-19-5"

  • CAS Number:
  • 87333-19-5
  • Name:

  • Ramipril

  • Molecular Structure:
  • Formula:
  • C23H32N2O5
  • Molecular Weight:
  • 416.52
  • Deleted CAS:
  • 126613-39-6
  • Synonyms:
  • Altace;Hytren;Carasel;Cardace;Vesdil;Pramace;Cyclopenta(b)pyrrole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-;Quark;HOE 498;Triatec;Acovil;(2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid.;
  • Density:
  • 1.2 g/cm3
  • Melting Point:
  • 106-108 °C
  • Boiling Point:
  • 616.2 °C at 760 mmHg
  • Flash Point:
  • 326.4 °C
  • Appearance:
  • White solid
  • Hazard Symbols:
  • IrritantXi
  • Risk Codes:
  • 36/38
  • Safety:
  • 26-37/39 Details
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CAS No.87333-19-5 RamiprilCompetitive Product

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CAS No.87333-19-5 RamiprilCompetitive Product

Assay:USP  Appearance:Crystalline ...  Package:25kg/drum

Product Name: Ramipril CAS#:87333-19-5 Appearance : Crystalline Powder Standard: USP Assay: USP Packing: 25kg/drum

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CAS No.87333-19-5 Ramipril

Category : Agrochemicals CAS NO : 87333-19-5 EC NO : MF : C23H32N2O5 MW : 416.52 Synonyms : (2S,3aS,6aS)-1((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid, 1-ethyl ester;Altace;(2s,3as,6as)-1-[(s)-2-[[(s)-1-(Ethoxycarbonyl)-3-P

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CAS No.87333-19-5 Ramipril

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CAS No.87333-19-5 Ramipril

Antihypertensive drugs for the treatment of high blood pressure, congestive heart failure and other diseases. Quality specification EP5 CAS:87333-19-5 Character:White or almost white crystalline powder Function:Antihypertensive drugs for the treatment of high blood pressur

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CAS No.87333-19-5 Ramipril

Ramipril belongs to a group of medications called ACE inhibitors. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

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CAS No.87333-19-5 Ramipril

(2s,3as,6as)-1-[(s)-2-[[(s)-1-(Ethoxycarbonyl)-3-Phenylpropyl]Amino]Propanoyl]Octahydrocyclo- penta-[b]Pyrrole-2-Carboxylic Acid - Pyrrole-2-Carboxylic Acid Molecular formula：C23H32N2O5 Molecular weight：416.50

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RAMIPRIL

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CAS No.87333-19-5 Ramipril

Ramipril BP/EP/USP Pronunciation: (ruh-MIH-prill) Class: Angiotensin converting enzyme (ACE) inhibitor

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CAS No.87333-19-5 Ramipril

Other Names 2S,3aS,6aS)-1((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocycl MF C23H32N2O5 Place of Origin Zhejiang, China (Mainland) Type Pharmaceutical Intermediates Brand Name CHANGMING Application antihypertensive drug

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Ramipril(Altace) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM.

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more information,please contact us

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Ramipril

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Reference

Pharmacokinetics and pharmacodynamics of a novel orally active angiotensin converting enzyme inhibitor (HOE 498) in healthy subjects
Pharmacokinetics and pharmacodynamics of a novel orally active angiotensin converting enzyme inhibitor (HOE 498) in healthy subjects. Witte, P. U.; Irmisch, R.; Hajdu, P.; Metzger, H. (Hoechst A.-G., Frankfurt/Main, Fed. Rep. Ger.). Eur. J. Clin. Pharmacol., 27(5), 577-81 (English) 1984. CODEN: EJCPAS. ISSN: 0031-6970. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacokinetics and pharmacodynamics of the angiotensin converting enzyme inhibitor HOE 498 [87333-19-5] were investigated in healthy normotensive male subjects. Serum levels of the active metabolite M 1 (dicarboxylic acid of HOE 498) [87269-97-4] were measured by HPLC up to 14 days after a single oral dose of 10 mg HOE 498. Peak serum concn. of M 1 (5-50 ng/mL) was obsd. 1.5-3.0 h after administration. The serum concn.-time curve of M 1 was polyphasic and exhibited a prolonged terminal phase with a half-life of approx. 110 h. Despite the long terminal half-life, M 1 could not be detected in urine >72 h after administration. The activity of the angiotensin converting enzyme in plasma was completely suppressed for up to 12 h, and 50% inhibition of the enzyme was still obsd. after 72 h.
2-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-azabi cyclo[3
2-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-azabi cyclo[3.3.0]octane-3-carboxylic acid (Hoe 498)-a new and highly effective angiotensin I converting enzyme inhibitor. Metzger, H.; Maier, R.; Sitter, C.; Stern, H. O. (Hoechst A.-G., Frankfurt/Main, Fed. Rep. Ger.). Arzneim.-Forsch., 34(10B), 1402-6 (English) 1984. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Hoe 498 (I) [87333-19-5] is a new, very effective and long lasting, nonsulfhydryl angiotensin I converting enzyme [9015-82-1] inhibitor. When using hippuryl-histidyl-leucine as substrate, the IC50 values for Hoe 498 and its diacid deriv. [87269-97-4] were 26 and 4.2 nmol/L, resp. Hoe 498 acts as a prodrug, being hydrolyzed by a serum esterase into its active diacid deriv. Hoe 498 or its diacid deriv. do not modulate the membrane bound adenylate cyclase system of tissues studied. The results are discussed with respect to the regulation of the angiotensin II synthesis and to the regulation of Ca2+ channels in membranes.
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