Reference

Effect of serotonin 1A agonist tandospirone on depression symptoms in senile patients with dementia

Effect of serotonin 1A agonist tandospirone on depression symptoms in senile patients with dementia. Masuda, Yutaka; Akagawa, Yusuke; Hishikawa, Yasuo (Psychosomatic Division, Akita University School of Medicine, Akita 010-8543, Japan). Human Psychopharmacology, 17(4), 191-193 (English) 2002 John Wiley & Sons Ltd. CODEN: HUPSEC. ISSN: 0885-6222.In this article, certain chemicals are used. One of their cas registry numbers is 87760-53-0 DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The treatment of depression in senile patients with dementia is difficult with the drugs used formerly. The effects of a new anxiolytic drug, tandospirone, were investigated on depression symptoms in nine senile patients with dementia using Hamilton Depression Rating Scale (HAM-D) items. Tandospirone improved the symptoms, esp. the depressive mood, agitation and anxiety, although a slight gastrointestinal symptom was found in one patient. The findings in the present study may suggest that tandospirone is a useful and comparatively safe drug for depression symptoms in senile patients with dementia. .

Anticonflict action of tandospirone in a modified Geller-Seifter conflict test in rats

Anticonflict action of tandospirone in a modified Geller-Seifter conflict test in rats. Shimizu, Hiroshi; Kumasaka, Yoshino; Tanaka, Hiroyasu; Hirose, Akira; Nakamura, Mitsutaka (Res. Lab., Sumitomo Pharm. Co., Ltd., Osaka 554, Japan). Jpn. J. Pharmacol., 58(3), 283-9 (English) 1992. CODEN: JJPAAZ. ISSN: 0021-5198. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Tandospirone is a novel non-benzodiazepine compd. possessing potent anxiolytic properties in a water lick conflict paradigm in rats and a high affinity for central 5-HT1A receptors.There are some reagents like 87760-53-0 is used in this study. In the present study, tandospirone was evaluated for anxiolytic activity in a modified Geller-Seifter conflict paradigm in rats. Tandospirone produced significant increases in the punished responding at doses of 1.25, 2.5 and 5.0 mg/kg, i.p. or 20 mg/kg, p.o., although it decreased unpunished responding at doses of 2.5 and 5.0 mg/kg, i.p. or 20 mg/kg, p.o. Likewise, diazepam was also effective after i.p.-administration in this test, and its min. ED was slightly higher than that of tandospirone. This suggests that tandospirone might be as effective in the treatment of anxiety as diazepam. The anticonflict action of tandospirone was not inhibited by Ro-15-1788, a benzodiazepine antagonist, although that of diazepam was completely inhibited. 8-OH-DPAT, a full agonist of 5-HT1A receptors, was also effective in this test with a high potency. Therefore, the possibility exists that the anticonflict action of tandospirone is related to its agonist action on 5-HT1A receptors, not on benzodiazepine receptors. .