Reference

Method for forming inclusion complex of contrast media and cyclodextrin or derivatives thereof

Method for forming inclusion complex of contrast media and cyclodextrin or derivatives thereof. Geckeler, Kurt E.; Jun, Seong Hyeon; Kang, Han Chang (Kwangju Institute of Science and Technology, S. Korea). Repub.Chemicals with cas numbers 73334-07-3 and 87771-40-2 also play role. Korean Kongkae Taeho Kongbo KR 2001084737 A 6 Sep 2001, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: A61K049-04. APPLICATION: KR 2000-9983 29 Feb 2000. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A method for forming an inclusion complex of contrast media and cyclodextrin or derivs. thereof by reacting contrast media and cyclodextrin or derivs. thereof is provided. Whereby, the complex minimizes adverse effects by shielding an adverse effect-inducing factor not to directly contact with a biomaterial. The inclusion complex of contrast media and cyclodextrin or derivs. thereof is obtained by mixing cyclodextrin or derivs. thereof and contrast media in a mole ratio of 1:1 to for 0.1 h to 7 days and can be used as contrast media in vivo. The contrast media is selected from the group consisting of sodium diatrizoate, ioversol, iohexol, iopromide and mixts. thereof. .

Positive interference from contrast media in cardiac troponin I immunoassays

All Rights Reserved. Positive interference from contrast media in cardiac troponin I immunoassays. Lin, Chien-Tsai; Lee, Hsiang-Chun; Voon, Wen-Chol; Yen, Hsueh-Wei; Tang, Min-Hua; Chin, Tan-Tzu; Chen, Wori-Reen; Chien, Wan-Ting; Lai, Wen-Ter; Sheu, Sheng-Hsiung (Laboratory of Catheterization, Kaohsiung Medical University, Kaohsiung, Taiwan). Kaohsiung Journal of Medical Sciences, 22(3), 107-113 (English) 2006 Elsevier (Singapore) Pte. Ltd. CODEN: KJMSFM. ISSN: 1607-551X. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Section cross-reference(s): 8, 14 Cardiac troponin I (cTnI) has been a sensitive and reliable marker of myocardial damage, and elevated levels of cTnI can indicate high risk for acute coronary syndrome. To det. how to intervene in possible cases of acute coronary syndrome, cTnI levels must be measured by immunoassay. However, cTnI immunoassay results are prone to interference from many substances such as heparin and common drugs. 13087-53-1 and 87771-40-2 are cas registry numbers. These chemicals are also mentioned in this article. The contrast media used in the coronary angiog. might also interfere with results. To explore this possibility, we performed two in vivo and two in vitro studies. In the first in vivo study, we evaluated the effects of contrast media on cTnI immunoassays by collecting blood samples from 45 patients undergoing coronary angiog. before and after the procedure. We used the Opus Magnum immunoassay system to measure cTnI levels. In the second in vivo study, we collected 25 blood samples from another group of patients also undergoing angiog. at various times before and after the procedure to det. cTnI values by both the Opus Magnum and ACCESS systems. In the first in vitro study, 12 different contrast media were treated as samples to disclose the potential interference of measurement in the two assay systems. In the second in vitro study, we made sequential dilns. of iopromide (Ultravist; Schering) with serum to explore their potential for interfering with the detection of cTnI by the Opus Magnum and ACCESS assays. In the first in vivo study using the Opus Magnum assay, cTnI concns. in samples taken after angiog. were significantly higher at 5 min than at 30 min, and, at 60 min, all cTnI concns. had dropped below the cutoff point. In the second in vivo study, we found a substantial difference in detection of cTnI by the Opus Magnum and ACCESS assays. All cTnI concns. checked by ACCESS assay were below the cutoff value. In our first in vitro study, the Opus Magnum assay gave false pos. results for all 12 contrast media; the ACCESS assay gave a pos. result for only one contrast medium, poppy-seed oil (Lipiodol; Guebert). In our second in vitro study, we found that, in the Opus Magnum assay, the more concd. the contrast medium, the higher the cTnI value, but not in the ACCESS assay. We conclude that contrast media may cause false-pos. results in cTnI assays and that, when contrast media are being used for angiog., cTnI results, esp. those based on samples taken within the first hour of the procedure, should be interpreted carefully. .