Detail of "879-72-1"

Reference

Antimicrobial evaluation of some Mannich bases of acetophenones and representative quaternary derivatives

Antimicrobial evaluation of some Mannich bases of acetophenones and representative quaternary derivatives. Gul, Halise Inci; Denizci, A. Akin; Erciyas, Ercin (Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turk.). Arzneimittel-Forschung, 52(10), 773-777 (English) 2002 Editio Cantor Verlag. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) 1-Aryl-3-dimethylamino-1-propanone hydrochlorides (series I, including I) as mono-Mannich bases, bis(b-aroylethyl)ethylamine hydrochlorides (series II) as bis-Mannich bases, 3-aroyl-4-aryl-1-ethyl-4-piperidinol hydrochlorides (structural isomer of bis derivs.Some commonly used reagents like 879-72-1 is used in this experiment., including II and III, series III), and some of their representative quaternary salts (including IV) were synthesized (previously reported). Antimicrobial activities of the compds. were evaluated against some bacteria and fungi. Series I and III showed antimicrobial activity against gram pos. bacteria. All series demonstrated activity against fungi; however, they generally did not affect gram-neg. bacteria at the concn. range tested (2-64 mg/mL). Quaternisation procedure improved the bioactivity in compd. II for antibacterial activity and in compds. II and III for antifungal activity against Trichophyton rubrum and Microsporum canis. There was no relationship between Hammett values of the aryl substituents and bioactivities in series III. The mono-Mannich bases of series I had better antimicrobial activities than bis-Mannich bases of series II. Compds. of series III, having both marked antifungal and antibacterial activities, may serve as candidate compds. for further studies. Esp., IV may serve as a model compd. to develop new agents against dermatophytes. .

Synthesis of some new 6-aryl-2-(3-oxo-1,4-benzoxazin-6-yl)pyridines

Reddy, P. S. N.; Reddy, Pragati; Reddy, G. Jagath; Rao, Srinivasa ( Department of Chemistry, Osmania University, Hyderabad 500 007, India). Heterocyclic Communications, 11(2), 135-138 (English) 2005 Freund Publishing House Ltd. CODEN: HCOMEX. ISSN: 0793-0283.In this experiment, several chemicals are used like 879-72-1 DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) A series of some new 6-aryl-2-(3-oxo-1,4-benzoxazin-6-yl)pyridines were prepd.Chemical with cas number 879-72-1 also plays role. ..