Detail of "87999-87-9"
- CAS Number:
- 87999-87-9
- Name:
2-Pyridinecarboxylicacid, 4-propyl-
- Molecular Structure:
- Formula:
- C9H11 N O2
- Molecular Weight:
- 165.19
- Synonyms:
- 4-N-PROPYLPYRIDINE-2-CARBOXYLIC ACID;4-N-PROPYLPYRIDINEPICOLINIC ACID
2-Pyridinecarboxylicacid, 4-propyl-
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Reference
- Synthesis and antimicrobial activity of clindamycin analogs: pirlimycin, a potent antibacterial agent
- Synthesis and antimicrobial activity of clindamycin analogs: pirlimycin, a potent antibacterial agent. Birkenmeyer, Robert D.; Kroll, Stephen J.; Lewis, Charles; Stern, Kurt F.; Zurenko, Gary E. (Res. Lab., Upjohn Co., Kalamazoo, MI 49001, USA). J. Med. Chem., 27(2), 216-23 (English) 1984. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 27, 33 Clindamycin analogs I (R1 = H, 3-Me, 4-Et, 4-Pr, 4-Bu, 4-tert-Bu, 5-Et, 6-Me, 6-Et) and II (R1 = same) were prepd. by condensing the corresponding pyridinecarboxylic acids III with amino sugar RH by the mixed anhydride method using ClCO2CH2CHMe2 and hydrogenating the resulting pyridinecarboxamides. The 2-, 3-, and 4-isomers of I (R1 = H) and II (R1 = H) were prepd. similarly. Analog IV and the 2R- and 2S-isomers of analogs V and VI were also prepd.In this experiment, several chemicals are used like 87999-87-9 and 79415-18-2 Pirlimycin (II, R = 4-Et) has significantly favorable changes in toxicity, metab., and antibacterial potency in relation to clindamycin (VII). .