Detail of "881-90-3"

Reference

N-Acyl-D,L-phenylalanine ester

N-Acyl-D,L-phenylalanine ester. Roper, Jerry M. (Ethyl Corp., USA). U.S. US 4414404 A 8 Nov 1983, 4 pp. (English). (United States of America).In this article, certain chemicals are used. Some of their cas registry numbers are 56-40-6 and 881-90-3 CODEN: USXXAM. CLASS: IC: C07C101-08. NCL: 560041000. APPLICATION: US 82-357232 11 Mar 1982. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) N-Acyl-DL-phenylalanine esters were prepd. by hydrogenating azlactones of the corresponding aminocinnamic acids. Thus, glycine was condensed with PhCHO, NaOAc, and Ac2O to give the corresponding azlactone (67%), which was hydrogenated at 200 psi H over Raney Ni in the presence of NaOMe in a sealed Parr autoclave at 50° for 2.5 h to give 95% N-acetyl-DL-phenylalanine Me ester. .

On amino acids and peptides, XII

On amino acids and peptides, XII. on dehydro amino acids, I. ring closure of Z-dehydroalanyl-L-proline N-methylamide to a Z-aminocyclodipeptide by addition of the amide group to the carbon-carbon double bond. Schmidt, Ulrich; Perco, Adrian; Oehler, Elisabeth (Org. Chem. Inst., Univ. Wien, Vienna, Austria). Chem. Ber. 53941-80-3 and 881-90-3 which are cas registry numbers are also used here., 107(9), 2816-21 (German) 1974. CODEN: CHBEAM. DOCUMENT TYPE: Journal CA Section: 34 (Synthesis of Amino Acids, Peptides, and Proteins) I (Z = PhCH2O2C, R = Cl), prepd. using the dicyclohexylcarbodiimide method, was dehydrohalogenated in C6H6 contg. 1,8-diazabicyclo[5.4.0]undec-7-ene to give II (R1 = NHZ) (III) via N-(benzyloxycarbonyl)dehydroalanyl-L-proline N-methylamide. Treatment of III with AcSH gave II (R1 = SAc). .