Detail of "88191-48-4"

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Catechin crystal modifications and pharmaceuticals containing them

Catechin crystal modifications and pharmaceuticals containing them. Marti, Erwin; Heiber, Oskar; Gumma, Alexandre; Huber, Gustave; Utsumi, Isamu; Nakagawa, Hiroshi; Miyata, Tatsuhiko; Akimoto, Koichi (Zyma S. A., Switz.). Ger. Offen. DE 3306092 A1 1 Sep 1983, 66 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D311-62; A61K031-35. APPLICATION: DE 83-3306092 22 Feb 1983. PRIORITY: GB 82-5453 24 Feb 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Crystal modifications of (+)-catechin monohydrate [88191-48-4] and anhyd.Several substances with their cas registry numbers 88191-49-5 and 154-23-4 may be metioned in this study. (+)-catechin [154-23-4] are prepd. for use in pharmaceuticals for treatment of liver disease. The modifications are highly stable to moisture and light. Lattice distances are given for the compds. An aq. soln. of (+)-catechin tetrahydrate [88191-49-5] was cooled from 75 to 50° over 3-4 h and inoculated with crystals of the a-monohydrate at 65°. The cooling was continued to 20° with stirring under N, and the a-monohydrate crystals were centrifuged and dried at 50°. The lattice distances and thermogravimetric properties of the crystals are tabulated. Formulations for flavored powders, tablets, capsules, and coated tablets are given. .

Characterization of Antioxidants and Change of Antioxidant Levels during Storage of Manilkara zapota L

Characterization of Antioxidants and Change of Antioxidant Levels during Storage of Manilkara zapota L. Shui, Guanghou; Wong, Shih Peng; Leong, Lai Peng (Food Science Technology Program, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore). Journal of Agricultural and Food Chemistry, 52(26), 7834-7841 (English) 2004 American Chemical Society. 88191-48-4 and 989-51-5 are also occured in this study. CODEN: JAFCAU. ISSN: 0021-8561. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Antioxidants found in fruits and vegetables play an important role via their protective effects against the onset of aging-related chronic diseases. Our previous research has indicated that unripe ciku fruits (Manilkara zapota L.) are an excellent source of antioxidants, with over 3000 mg of L-ascorbic acid equiv. antioxidant capacity (AEAC) per 100 g of fresh sample. In this study, 24 antioxidants in an ext. of ciku king were characterized through a free radical spiking test. Their chem. structures were proposed using high-performance liq. chromatog.-mass spectrometry (HPLC-MS) and tandem MS (HPLC/MSn). The antioxidant capacity of ciku king fruits was mainly attributed to polyphenolics with basic blocks of gallocatechin or catechin or both. The changes of total antioxidant capacity (TAC) and total phenolics content (TPC) of ciku king fruits with storage time were also investigated. It was found that the TAC and TPC decreased significantly as the fruits gradually changed from the unripe to the overripe stage. The best time for one to consume ciku king fruits at a flavorful stage with high amts. of antioxidants with AEAC values ranging from 600 to 1200 mg per 100 g fresh sample is suggested. The change of the content of major antioxidant peaks was also consistent with changes of antioxidant levels during storage. .