Detail of "883-87-4"

CAS Number:
883-87-4
Name:
Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, hydrochloride (1:1), (1S)-
Molecular Structure:
Formula:
C12H17 N O2 . Cl H
Molecular Weight:
243.7298
Synonyms:
Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, hydrochloride, (1S)- (9CI);Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, hydrochloride, (S)-;Salsolidine, hydrochloride (7CI,8CI); (-)-Salsolidine hydrochloride
EINECS:
212-934-8
Melting Point:
189-192 °C
Boiling Point:
313.4 °C at 760 mmHg
Flash Point:
127.1 °C
Hazard Symbols:
Xn
Risk Codes:
36/37/38-22
Safety:
37/39-26 Details

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Studies on the standardization of conditions for the gas-chromatographic analysis of some drugs manufactured from derivatives of nitrogen-containing heterocyclic compounds: Nesterova, G. A.; Trubnikov, V. I.; Yaskina, D. Z.; Sakodynskii, K. I. (Fiz.-Khim. Inst. im. Karpova, Moscow, USSR). Deposited Doc., VINITI 843-75, 25 pp. Avail. BLLD (Russian) 1975. DOCUMENT TYPE: Report CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 27 Gas chromatog. expts. are described for the detn. of esters of isocinchomeronic, quinolinic, and dipicolinic acids and of papaverine-HCl [61-25-6], dibazole [621-72-7], phenobarbital [50-06-6], salsoline-HCl [881-26-5], and salsolidine-HCl [883-87-4] using isocinchomeronic acid diethyl ester (I) [5552-44-3] and its dipropyl [136-45-8] and diheptyl ester [63597-08-0] as internal stds. The detn. of papaverine-HCl and dibazole in Papazole [59947-86-3] tablets is emphasized. 63597-06-8 is the cas registry number of certain chemical which is used as reagents here. .

Effect of tablet excipients on alkaloid and phenobarbital uptake by isolated rat intestine: Effect of tablet excipients on alkaloid and phenobarbital uptake by isolated rat intestine. Ishchenko, V. I. (Vitebsk. Med. Inst., Vitebsk, USSR). Farmatsiya (Moscow), (4), 19-23 (Russian) 1978. CODEN: FRMTAL. ISSN: 0367-3014. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Tablet additives glucose [50-99-7], sucrose [57-50-1], and lactose [63-42-3] reduced the caffeine [58-08-2], theobromine [83-67-0], and theophylline [58-55-9] uptake in rat small intestine by 30-40%, whereas glycocol [56-40-6], KH2PO4, basic MgCO3, mannitol [69-65-8], NaHCO3 and NaCl had no significant effect. Na CM-cellulose [9004-32-4], poly(vinylpyrrolidinone) [9003-39-8], and poly(vinyl alc.) [9002-89-5] reduced the uptake rate of caffeine, theobromine, theophylline, codeine [76-57-3], papaverine-HCl [61-25-6], salsolidine-HCl [883-87-4], quinine-HCl [7549-43-1] and phenobarbital [50-06-6] by 30-50%. Gelatin reduced the uptake slightly and starch [9005-25-8] had no effect on the uptake of either the alkaloids or phenobarbital. Tween 80 [9005-65-6] in submicellar concns. increased the phenobarbital uptake by 20-50% and that of caffeine, theobromine, theophylline, codeine and papaverine by 10-30%.