Detail of "88321-09-9"

CAS Number:
88321-09-9
Name:
2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-
Superlist Name:
Aloxistatin
Molecular Structure:
Formula:
C17H30 N2 O5
Molecular Weight:
342.49
Synonyms:
Oxiranecarboxylicacid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)- (9CI); Oxiranecarboxylic acid,3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethylester, [2S-[2a,3b(R*)]]-; Aloxistatin; E 64c ethylester; E 64d; EP 453; EST; EST (pharmaceutical); Loxistatin; NSC 694281
Hazard Symbols:
Risk Codes:
36/37/38
Safety:
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Details

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L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

Supplier:Alabiochem. Tech.Co., Ltd. [ China (Mainland)]

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Tel:+86-512-56727736

Address:No.1, North of GuoTai Road

Supplier:Cayman Chemical Company [ United States]

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Tel:(800) 364-9897

Address:1180 East Ellsworth Road Ann Arbor, Michigan 48108 USA

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Characterization of three new analogs of E-64 and their therapeutic application: Characterization of three new analogs of E-64 and their therapeutic application. Hanada, Kazunori; Tamai, Masaharu; Adachi, Takashi; Oguma, Kiyoshi; Kashiwagi, Keiko; Ohmura, Sadafumi; Kominami, Eiki; Towatari, Takae; Katunuma, Nobuhiko (Res. Cent., Taisho Pharm. Co., Ltd., Saitama 330, Japan). Proteinase Inhib., 25-36. Edited by: Katunuma, Nobuhiko; Umezawa, Hamao; Holzer, Helmut. Japan Sci. 66701-25-5 and 76739-51-0 are cas registry numbers of chemicals which are used as reagents here. Soc. Press: Tokyo, Japan. (English) 1983. CODEN: 50PVAZ. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) The pharmacol. of Ep-459 [76739-51-0], Ep-475 [76684-89-4], and Ep-453 [88321-09-9], analogs of the protease inhibitor E-64, is described. .

Toxicological studies on ethyl (+)-(2S,3S)-3-[(S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl]- 2-oxiranecarboxylate (EST): Toxicological studies on ethyl (+)-(2S,3S)-3-[(S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl]- 2-oxiranecarboxylate (EST). IX. Mutagenicity of EST. Yasui, Hajime; Goto, Hiromi; Suzuki, Hiroshi; Sakai, Shigeru; Takamura, Tadanobu; Nakane, Sadao (Res. Cent., Taisho Pharm. Co., Ltd., Ohmiya 330, Japan). Iyakuhin Kenkyu, 17(4), 815-25 (Japanese) 1986. CODEN: IYKEDH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In vitro tests (Ames test in Salmonella typhimurium strains and in Escherichia coli WP2 urA and chromosome aberration test in Chinese hamster lung fibroblast cells) and in vivo bone-marrow chromosome aberration and bone-marrow micronucleus tests showed that the title compd. (I) [88321-09-9], is unlikely to posses mutagenicity in vivo.