Detail of "88444-81-9"

Reference

Process for preparation of arylethynylpyrazole derivatives

Process for preparation of arylethynylpyrazole derivatives. Urata, Takao; Sumitani, Naoko; He, Liangyou (Agro-Kanesho Co., Ltd., Japan). PCT Int. Appl. WO 2004026839 A1 1 Apr 2004, 24 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. 88444-81-9 which is the cas registry number is also used here. (Japanese). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D231-12. APPLICATION: WO 2003-JP12012 19 Sep 2003. PRIORITY: JP 2002-272480 19 Sep 2002. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 45 This invention pertains to a method for producing arylethynylpyrazole derivs. with general formula of I [R1 = H, halo, (un)substituted alkyl, alkenyl, alkynyl, alkoxy, or aryl; R2 = H, alkyl, haloalkyl, or (un)substituted aryl; R3 = alkyl, aralkyl, or aryl; X = halo], which comprises the coupling reaction of a halogenated pyrazole compd. with an arylacetylene compd. in the presence of a copper halide catalyst and a base. For example, 3,5-bis(trifluoromethyl)phenylacetylene (prepn. given) was coupled with 1-methyl-4-iodo-3-trifluoromethylpyrazole-5-acetic acid Me ester (prepn. given) in DMF in the presence of CuI and K2CO3 to give II (72%) with 98.6% purity. This invention provides a method to enable the coupling reaction at low cost with easy operation. .