Detail of "88519-57-7"

Reference

Inhibition of human breast cancer colony formation by anticalmodulin agents: trifluoperazine, W-7, and W-13

Inhibition of human breast cancer colony formation by anticalmodulin agents: trifluoperazine, W-7, and W-13. Wei, Jiann Wu; Hickie, Robert A.; Klaassen, David J. (Dep. Pharmacol., Univ. Saskatchewan, Saskatoon, SK S7N 0W0, Can.). Cancer Chemother. Pharmacol., 11(2), 86-90 (English) 1983. CODEN: CCPHDZ. ISSN: 0344-5704. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of anticalmodulin agents, namely trifluoperazine (TFP) [117-89-5] and 2 naphthalenesulfonamide derivs. (W-7 [65595-90-6] and W-13 [88519-57-7]), were tested on the growth of a human breast cancer cell line (MDA-MB-231) using a soft agar clonogenic assay. TFP, W-7, and W-13 had the ability to inhibit the colony formation from this cell line. The inhibitory effect was greater when the cancer cells were exposed to these agents continuously than when the cells were exposed to the drugs for 1 h. 88519-57-7 and 117-89-5 which are cas registry numbers of chemicals are mentioned. The IC50 values for TFP, W-7, and W-13 in continuous exposure were about 18, 30, and 38 mM, resp., whereas the corresponding values for 1-h exposure were 50, 53, and 70 mM, resp. Apparently, anticalmodulin agents can inhibit the growth of human cancer cells at relatively low concns. in vitro. Whether effective antitumor concns. of these drugs can be achieved in vivo remains a subject for further study. .

Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels

Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels. Greenberg, David A.; Carpenter, Celia L.; Messing, Robert O. (Dep. Neurol., Univ. California, San Francisco, CA 94110, USA). Brain Res., 404(1-2), 401-4 (English) 1987. CODEN: BRREAP. ISSN: 0006-8993. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 13 The relative abilities of a series of calmodulin inhibitors and protein kinase [9026-43-1] C inhibitors to influence 45Ca2+ influx through voltage-dependent Ca2+ channels in PC12, a clonal neural cell line were studied.There are some commonly used reagents with their cas registry numbers 79458-81-4 and 88519-57-7 in this article. K+-depolarization-dependent 45Ca2+ uptake was reduced by the calmodulin inhibitors calmidazolium [95013-41-5], trifluoperazine [117-89-5], W-7 [65595-90-6], W-13 [88519-57-7], and W-5 [79458-81-4] at concns. comparable to those that affect calmodulin, whereas the proteins kinase C inhibitors polymyxin B [1404-26-8] and H-7 [84477-87-2] were weak or ineffective. The Ca2+ channel antagonist properties of calmodulin inhibitors should be considered in interpreting their effects on Ca2+-dependent cellular events. .