Detail of "88527-77-9"

Reference

Effectiveness of nitrosomethylurea derivatives in combined chemotherapy of experimental tumors

Effectiveness of nitrosomethylurea derivatives in combined chemotherapy of experimental tumors. Krutova, T. V.; Ostrovskaya, L. A. (Inst. Chem. Phys., Moscow 117977, USSR). Eksp. Onkol., 8(5), 47-50 (Russian) 1986. CODEN: EKSODD. ISSN: 0204-3564. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The antitumor activity of the combined application of the nitrosomethylurea derivs. dimethylnitrosourea [13256-32-1] and ADEKO [88527-77-9] with cyctostatics of various groups was studied in transplanted tumors of La and L1210 leukemias and Lewis lung carcinoma. Combined treatment with ADEKO and cyclophosphamide [50-18-0], methotrexate [59-05-2], and dibunol [128-37-0] resulted in therapeutic synergism evaluated by the tumor growth inhibition activity and by life span increase of tumor-bearing animals. An additive antitumor effect was established in combined application of ADEKO with ftorafur [17902-23-7], vincristine [57-22-7], prednisolone [50-24-8] and dimethylnitrosourea with methotrexate.

Assessment of lethal and cytostatic effects of alkylnitrosoureas on the cells of experimental tumors

Assessment of lethal and cytostatic effects of alkylnitrosoureas on the cells of experimental tumors. Emanuel, N. M.; Ostrovskaya, L. A.; Krutova, T. V.; Konradov, A. A. (Inst. Chem. Phys., Moscow 117977, USSR). Neoplasma, 31(5), 529-38 (English) 1984. CODEN: NEOLA4. ISSN: 0028-2685. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A math. model for the assessment of the cytolethal and cytostatic effects of various alkylnitrosoureas (alone or, in the case of 1,3-dimethyl-1-nitrosourea [13256-32-1] and ADEKO [88527-77-9], in combination with cyclophosphamide [50-18-0]) was evaluated. The synergistic therapeutic effect of ADEKO with cyclophosphamide against NK/Ly ascites and Lewis lung carcinoma in mice was predicted with the model.