Reference

Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats

Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats. Van der Graaff, M.; Vermeulen, N. P. E.; Joeres, R. P.; Vlietstra, T.; Breimer, D. D.Chemicals with cas numbers 18125-49-0 and 7391-67-5 also play role. (Gorlaeus Lab., Univ. Leiden, Leiden 2300 RA, Neth.). J. Pharmacol. Exp. Ther., 227(2), 459-65 (English) 1983. CODEN: JPETAB. ISSN: 0022-3565. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Two model substrates for oxidative hepatic enzyme activity, viz., hexobarbital (HB) [56-29-1] and antipyrine (AP) [60-80-0], were given simultaneously to rats by the oral route. Blood concns. of HB and AP were measured simultaneously, and the urinary excretion of 6 metabolites arising from AP and HB also was detd.: norantipyrine [89-25-8], 4-hydroxyantipyrine [1672-63-5], 3-hydroxymethylantipyrine (HMA) [18125-49-0], 3'-hydroxyhexobarbital [427-29-2], 3'-ketohexobarbital [427-30-5], and 1,5-dimethylbarbituric acid [7391-67-5]. The apparent intrinsic clearances of HB (CLint,HB) and AP (CLint,AP) and the clearance for prodn. of the various metabolites were correlated in an attempt to establish whether HB and AP have metabolic pathways mediated by the same or very similar forms of cytochrome P 450 [9035-51-2]. In order to create broadly ranging and evenly distributed clearance values, 3-methylcholanthrene (3-MC) [56-49-5]- and phenobarbital (PB) [50-06-6]-pretreated rats were employed in conjunction with a control group of untreated animals. CLint,HB and CLint,APwere both increased by PB pretreatment, but 3-MC pretreatment increased CLint,,AP, whereas CLint,HB was decreased. CLint,HB and CLint,APcorrelated poorly, when all groups were taken into consideration. The formation of AP metabolites was inducible by both PB and 3-MC, and good correlations between rates of formation of AP metabolites and CLint,HB and CL3'-hydroxy-HB + 3'-keto-HB were obtained. When data from 3-MC-pretreated rats were included, only the correlations with CLHMA maintained a high value, permitting the conclusion that allylic oxidn. of HB, and HMA formation in AP metab., are most probably mediated by the same or a very similar form of cytochrome P 450. These results support the hypothesis that a good method for elucidating correlations in drug metab., in vivo, is giving the substances simultaneously by the oral route and taking into account the various pathways of metab. .

Disperse 1:2 metal complex dyes for dyeing of polyamide fibers during production

Disperse 1:2 metal complex dyes for dyeing of polyamide fibers during production. Kraska, Jan; Kuswik, Jan (Inst. Barwnikow, Politech. Lodzka, Lodz, Pol.). Przegl. Wlok., 37(10-11), 369-72 (Polish) 1983. CODEN: PRZWAZ. ISSN: 0033-2410. DOCUMENT TYPE: Journal CA Section: 41 (Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers) Azo dyes were prepd. by alk. 90163-35-2 and 90163-29-4 are also in the experiment. coupling of diazotized anthranilic acid (I) [118-92-3] and diazotized substituted 2-aminophenols with 3-methyl-1-phenyl-5-pyrazolone [89-25-8] and its derivs. substituted on the benzene ring, and alk. coupling of diazotized substituted 2-aminophenols with 1-naphthol [90-15-3], 2-naphthol [135-19-3], and their derivs. The resulting azo dyes (27) were metalized by treatment with Cr(OAc)3 (dyes derived from I), and Na chromosalicylate or CoCl2 (dyes derived from aminophenols). The wavelength of max. light absorption, molar absorptivity, lightfastness (Xenotest), and color (ranging from yellow to black) of the dyes were reported. .