Detail of "89-35-0"

Reference

Naphthamide derivatives

Naphthamide derivatives. Sekine, Yasuo; Yamaura, Tetsuaki; Nishimura, Masato; Kojima, Eri; Emoto, Yasuko; Higashide, Yasushi (Fujirebio Inc., Japan). Eur. Pat. Appl. EP 492178 A2 1 Jul 1992, 65 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D333-18. ICS: C07D207-12; C07D295-12; C07D213-32; C07D213-38; C07D211-46; C07D213-30; C07D307-38; C07D401-12; A61K031-38; A61K031-40. ICA: A61K031-495; A61K031-445; A61K031-34; A61K031-44. APPLICATION: EP 91-120553 29 Nov 1991. PRIORITY: JP 90-330004 30 Nov 1990. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 25, 27, 63 Naphthamides I [R1, R2, R3 = H, halo, OH, alkyl, alkoxy, alkanoyloxyalkyl, alkoxyalkyl, alkanoyloxyalkyl, aralkoxy; R4 = H, alkyl; R5 = (un)substituted aryl, (un)substituted heteroarom.; X = CHR6 (a cycloalkylene, bivalent N-contg. heterocyclic group, or NR7, -R8-, NH, NHR8 (R6, R7 = H, alkyl, R8 = cycloalkylene, R6R7R4 = C1-3 alkylene); Y = S, SO, SO2, (CH2)n (n = 0, 1), O; Z = un(substituted)alkylene, bond; l = 0-4, m = 0-8, q = 0-1], useful as lipoxygenase inhibitors were prepd. Thus, amidation of 3,5-dihydroxy-2-naphthoic acid 5-acetate with 1-(2-aminoethyl)-4-(benhydryloxy)piperidine, prepd. in 4 steps from benzhydrol and N-acetyl-4-(mesyloxy)piperidine, gave 73% naphthamide II, useful as a 5-lipoxygenase inhibitor, thromboxane inhibitor, and as an antihistaminic. 89-35-0 is also in the experiment. .