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89-77-0

Basic Information
CAS No.: 89-77-0
Name: 2-Amino-4-chlorobenzoic acid
Article Data: 28
Molecular Structure:
Molecular Structure of 89-77-0 (2-Amino-4-chlorobenzoic acid)
Formula: C7H6ClNO2
Molecular Weight: 171.583
Synonyms: 4-Chloroanthranil acid;2-amino-4-chlorobenzoic-acid;2-amino-4-chloro-benzoate;Anthranilic acid, 4-chloro-;4-Chloroanthranilic acid;4-14-00-01072 (Beilstein Handbook Reference);4-Chloro-2-Aminobenzoic acid;2-amino-4-chloro-benzoic acid;Anthranilic acid, 4-chloro- (6CI,7CI,8CI);Benzoic acid, 2-amino-4-chloro-;
EINECS: 201-938-5
Density: 1.476 g/cm3
Melting Point: 231-233 °C(lit.)
Boiling Point: 351.2 °C at 760 mmHg
Flash Point: 166.2 °C
Solubility: slightly soluble in water
Appearance: off-white powder
Hazard Symbols: HarmfulXn, IrritantXi
Risk Codes: 36/37/38-20/21/22
Safety: 26-36-37/39
PSA: 63.32000
LogP: 2.20160
Synthetic route
50-84-0

2,4 dichlorobenzoic acid

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With ammonium hydroxide at 126 - 129℃; under 3800 - 9120 Torr; for 6h;88%
With ammonia; copper at 120℃;
66909-52-2

2,4-dichlorobenzoic acid potassium salt

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With ammonium hydroxide; copper diacetate at 126 - 129℃; for 10h;68%
6280-88-2

4-chloro-2-nitro-benzoic acid

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With tin(II) chloride dihdyrate In ethanol for 1h; Inert atmosphere;23%
With platinum Hydrogenation;
With ammonia; iron(II) sulfate
6341-92-0

6-chloroisatin

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide
5900-59-4

2-amino-4-chlorobenzamide

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid
61680-22-6

7-chloro-3-(3-chlorophenyl)quinazoline-2,4(1H,3H)-dione

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With potassium hydroxide
96385-49-8

4-chlorophthalamide

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With alkaline aqueous potassium hypobromite
5900-56-1

2-acetylamino-4-chlorobenzoic acid

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride Zers. des entstandenen Hydrochlorids mit Natriumacetat;
67-56-1

methanol

6341-92-0

6-chloroisatin

A

5900-58-3

2-amino-4-chloro-benzoic acid methyl ester

B

89-77-0

2-Amino-4-chlorobenzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide; sodium methylate 1.) 0-10 deg C 2.) room temperature, 30 min; Yield given. Multistep reaction;
7147-90-2

4-chlorophthalimide

alkaline hypochlorite

alkaline hypochlorite

A

89-77-0

2-Amino-4-chlorobenzoic acid

B

N-<5-chloro-2-amino-benzoyl>-<5-chloro-2-amino-benzoic acid >(?)

N-<5-chloro-2-amino-benzoyl>-<5-chloro-2-amino-benzoic acid >(?)

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Chemistry

The Molecular formula of  2-Amino-4-chlorobenzoic acid(89-77-0) :  C7H6ClNO2
The Molecular Weight of   2-Amino-4-chlorobenzoic acid(89-77-0):  171.58
Molecular Structure :
Melting point:  231-235 oC
WATER solubility:  slightly soluble
Appearance: White or yellowish crystal

Uses

2-Amino-4-chlorobenzoic acid(89-77-0)  is a intermediate for pharmaceuticals, and other organic products

Toxicity Data With Reference

Irritating to eyes, respiratory system and skin.The toxicological properties of 2-Amino-4-chlorobenzoic acid(89-77-0) have not been fully investigated.
Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation.
Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation: May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema.

Safety Profile

The Hazard Codes of  2-Amino-4-chlorobenzoic acid(89-77-0) :  Xi   
The Risk Statements information of 2-Amino-4-chlorobenzoic acid(89-77-0) :  
36/37/38:  Irritating to eyes, respiratory system and skin 
The Safety Statements information of 2-Amino-4-chlorobenzoic acid(89-77-0): 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
37/39:  Wear suitable gloves and eye/face protection

Standards and Recommendations

PURITY (HPLC): 98.0% min
MOISTURE:  0.2% max

Specification

Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: CARBON monoxide, oxides of NITROGEN, CARBON DIOXIDE.
Hazardous Polymerization: Has not been reported.