Reference

Studies on the percutaneous absorption of paeonol by using stable isotopes

Studies on the percutaneous absorption of paeonol by using stable isotopes. Mimura, Kunio; Baba, Shigeo (Tokyo Coll. Pharm., Hachioji 192-03, Japan). Chem. Pharm. Bull., 31(10), 3698-706 (English) 1983. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 Studies on the percutaneous absorption, metab. and excretion of paeonol (I) [552-41-0] were carried out by using the stable isotope (SI) method. Hydrophilic ointment or absorptive ointment contg. 5% I was topically applied under an occlusive dressing to man and rat for 6, 12 and 24 h. The amts. of metabolites (2,5-dihydroxy-4-methoxyacetophenone [22089-12-9], resacetophenone [89-84-9], and unchanged substrate I excreted in the urine were detd. by selected ion monitoring assay. After topical application of hydrophilic ointment for 6 h in man, the amts. 22089-12-9 and 552-41-0 are also in the experiment. of I, and its metabolites in 0-24 h urine were 3.35, 16.28 and 5.17% of the applied dose, resp. Urinary excretion of I metabolites continued for 6 d from the time of application, but the total amt. of metabolites excreted in 0-24 h was as much as 89% of that excreted in 0-144 h. The SI tracer technique is reproducible and appears to have sufficient sensitivity to use in studying percutaneous drug absorption. Paeonol is easily absorbed through the skin, and the metabolites are excreted rapidly in urine. .

Study on the absorption, distribution, metabolism and excretion of paeonol, a main component of Paeonia moutan Sins, in rats

Study on the absorption, distribution, metabolism and excretion of paeonol, a main component of Paeonia moutan Sins, in rats. Yokoyama, Toshio; Hayase, Yukitoshi; Aikawa, Hiroshi; Odaka, Yoshichika; Miyamoto, Sadaichi; Mori, Yo (Cent. Res. Lab., SS Pharm. Co., Ltd., Tokyo, Japan). Oyo Yakuri, 13(3), 457-64 (Japanese) 1977. CODEN: OYYAA2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In the rat, the blood levels of radioactivity reached the max. 20 min after an oral administration of 14C-labeled paeonol (I) [552-41-0] (16 mg/100 mCi/kg) and then decreased rapidly. The half-life was about 30 min. A higher concn. of radioactivity was obsd. in the liver, kidney and a lower concn. in the brain, muscle and testis. After an oral administration, 88% and 5% of the radioactivity were excreted in urine and feces at 24 h, resp. The cumulative excretion of radioactivity was about 95% in urine and feces within 4 days. The metabolites in a 7 h urine were conjugates of I, 2,5-dihydroxy-4-methoxyacetophenone [22089-12-9] and resacetophenone [89-84-9].