Detail of "890-38-0"

Reference

Purinergic control of anxiety: direct behavioral evidence in the rat

Purinergic control of anxiety: direct behavioral evidence in the rat.Some chemicals with cas registry numbers like 20245-33-4 and 604-75-1 are also used. Wagner, J. A.; Katz, R. J. (Dep. Psycol., Johns Hopkins Univ., Baltimore, MD 21218, USA). Neurosci. Lett., 43(2-3), 333-7 (English) 1983. CODEN: NELED5. ISSN: 0304-3940. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 2'-Deoxyinosine [890-38-0], and to a lesser extent 7-methylinosine [20245-33-4], produced an operationally defined conditioned anxiety response, as expressed by a decrease in the preference for a dark when given the choice of dark and brightly lit chambers after prior treatment with the drugs during confinement in the dark. The effect was abolished by the benzodiazepine oxazepam [604-75-1], indicating that the behavioral effects were mediated by binding of the inosines to benzodiazepine receptors. Simple motor deficits or general malaise could not account for the anxiogenic response. .

Adenine nucleotide levels and adenosine metabolism in cultured calvarial bone

Adenine nucleotide levels and adenosine metabolism in cultured calvarial bone. Fredholm, Bertil B.; Lerner, Ulf (Dep. Pharmacol., Karolinska Inst., Stockholm S-104 01, Swed.). Acta Physiol. Scand., 120(4), 551-5 (English) 1984. CODEN: APSCAX. ISSN: 0001-6772. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 13 Adenine nucleotide levels were measured in exts. of murine calvaria after different periods of culture with or without parathyroid hormone (PTH) [9002-64-6] (10-8M) or PGE2 [363-24-6] (10-7M). In control calvaria the energy charge remained ~0.7 for 24 h. However, bones cultured with PTH or PGE2 showed a transient fall in the energy charge down to 0.5. This was not assocd. 58-64-0 and 73-24-5 are cas registry numbers of chemicals which are used as reagents here. with a fall in total adenine nucleotides. The rate of adenosine [58-61-7] metab. in cultured bone in vitro was studied by detg. the contents of adenosine, inosine [58-63-9], 5-deoxyadenosine [58-64-0], 2-deoxyinosine [890-38-0], and hypoxanthine [68-94-0] in the culture medium. There was a continuous increase in adenosine, inosine, and hypoxanthine as well as a disappearance of medium 2-deoxyadenosine that was accounted for by appearance of 2-deoxyinosine. The deaminating activity could be accounted for only partly by activity in the medium and thus the main activity probably resides in the bone cells. PTH (10-8M) did not alter the rate of disappearance of 2-deoxyadenosine or adenosine deaminease activity detd. in bone exts. Thus, 2 substances that increase Ca2+ mobilization from bone alter ATP utilization and(or) synthesis without significantly influencing adenosine prodn. or metab. .