Detail of "89226-50-6"

Reference

Manidipine: a review of its use in the management of hypertension

Manidipine: a review of its use in the management of hypertension. McKeage, Kate; Scott, Lesley J. (Adis International Limited, Auckland, N. Z.). Drugs, 64(17), 1923-1940 (English) 2004 Adis International Ltd. CODEN: DRUGAY. ISSN: 0012-6667. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. In addn., manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation. It has a gradual onset of action and a long duration of action enabling once daily administration. Furthermore, manidipine dilates both the efferent and the afferent renal arterioles and appears to have beneficial renal effects unrelated to its antihypertensive effect. Once-daily oral manidipine is an effective and generally well tolerated antihypertensive agent for younger and elderly adult patients with mild-to-moderate hypertension. 89226-50-6 and 9004-10-8 which are cas registry numbers of substances are two of reagents here. In particular, in a large double-blind trial, the incidence of ankle edema was significantly lower in manidipine than in amlodipine recipients. Manidipine is also effective in hypertensive patients with comorbidities, such as type 2 diabetes mellitus and/or renal impairment, and appears to improve insulin sensitivity without affecting metabolic function. Thus, manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension. .

Effects of nitrendipine, manidipine and nicardipine on regional blood flow in conscious spontaneously hypertensive rats

Effects of nitrendipine, manidipine and nicardipine on regional blood flow in conscious spontaneously hypertensive rats. Nakagawa, Haruto; Kawahara, Kiminori (Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Japan). Yakuri to Chiryo, 24(11), 2367-2373 (Japanese) 1996 Raifu Saiensu Shuppan K.K. CODEN: YACHDS. ISSN: 0386-3603. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The hemodynamic effects of nitrendipine, manidipine and nicardipine were examd. in conscious, spontaneously hypertensive rats. Nitrendipine (3 mg/kg, orally) reduced mean arterial pressure and total peripheral resistance (by 21.1%) and increased cardiac output (by 8.1%). Similar effects were produced by manidipine (3 mg/kg, orally) and nicardipine (3 mg/kg, orally). Nitrendipine increased cerebral, coronary and renal blood flows, as did nicardipine. 55985-32-5 and 89226-50-6 which are cas registry numbers of chemicals are mentioned. On the other hand, manidipine increased coronary and renal blood flows but had no effect on cerebral blood flow. In addn., nitrendipine decreased brain, heart, kidney, stomach and liver vascular resistance. These results indicate that the hypotensive action of nitrendipine is accompanied by an increase in blood flow to the major organs, including the brain; circulation in the latter is not pos. affected by manidipine. .