Detail of "89352-67-0"

CAS Number:
89352-67-0
Name:
L-Leucine,N,N-di-2-propen-1-yl-L-tyrosyl-2-methylalanyl-L-phenylalanyl-
Molecular Structure:
Formula:
C34H46 N4 O6
Molecular Weight:
606.7522
Synonyms:
L-Leucine,N,N-di-2-propenyl-L-tyrosyl-2-methylalanyl-L-phenylalanyl- (9CI); L-Leucine,N-[N-[N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl]-L-phenylalanyl]-; ICI174864; NIH 10893
Density:
1.16 g/cm³
Boiling Point:
892.7 °C at 760 mmHg
Flash Point:
493.7 °C
Appearance:
white solid

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Effects of delta opioid antagonists on enkephalin-induced seizures: Effects of delta opioid antagonists on enkephalin-induced seizures. Haffmans, Judith; Dzoljic, Mihailo R. (Med. Fac., Erasmus Univ., Rotterdam NL-3000DR, Neth.). Pharmacology, 34(2-3), 61-5 (English) 1987. CODEN: PHMGBN. ISSN: 0031-7012. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 The effect of opioid receptor antagonists on the seizure phenomena induced by the specific d-opioid receptor agonist [D-Ser2,Leu5]enkephalyl-Thr (DSLET) [75644-90-5] was examd. in rats. Two selective d-opioid receptor antagonists, ICI 154129 [83420-94-4] and ICI 174864 [89352-67-0] inhibited DSLET-induced epileptiform electrocorticogram pattern and myoclonic contractions in a dose-related manner. An equimolar concn. of naloxone failed to antagonize the epileptiform effects of DSLET. Evidently, d-opioid receptor agonist-induced seizure is mediated by d-receptors, since it can be blocked by d-opioid receptor antagonists. 83420-94-4 and 75644-90-5 are just another two chemicals used in this study. These d-opioid antagonists are a good tool to demonstrate a d-component in the seizure phenomena induced by other endogenous opioid peptides or their derivs. .

Selective d-opioid receptor antagonism by ICI 174864 in the central nervous system: Selective d-opioid receptor antagonism by ICI 174864 in the central nervous system. Dray, A.; Nunan, L. (Health Sci. Cent., Univ. Arizona, Tucson, AZ 85724, USA). Peptides (Fayetteville, N. Y.), 5(5), 1015-16 (English) 1984. CODEN: PPTDD5. ISSN: 0196-9781. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of the novel g-opioid receptor antagonist ICI 174864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH: Aib = a-aminoisobutyric acid) [89352-67-0] were examd. in the central nervous system in vivo using spontaneous reflex contractions of the rat urinary bladder as an index of activity. Bladder contractions were inhibited by equipotent intracerebroventricular (ICV) doses of the selective m-agonist [D-Ala2,MePhe4,Gly-(ol)5]enkephalin [78123-71-4] and the d-agonist DPDPE [D-Pen2,D-Pen5]enkephalin [88381-29-7]. ICI 174864 (1-3 mg) administered by the same route produced a selective and reversible antagonism of DPDPE effects. At higher doses (6-15 mg, ICV) ICI 174864 exhibited marked agonistic activity, producing inhibition of bladder contractions that were resistant to ICV naloxone (1-2 mg). Thus, ICI 174864 was considered a selective central d-opioid receptor antagonist but its usefulness was limited by addnl. agonistic properties.