Detail of "89943-82-8"

Reference

Stimulation of potassium fluxes by natriuretic furopyridines in human erythrocytes

Stimulation of potassium fluxes by natriuretic furopyridines in human erythrocytes. Braquet, Pierre; Garay, Ricardo (I.H.B., Le Plessis-Robinson, Fr.). Diuretics: Chem., Pharmacol., Clin. Appl., Proc. Int. Conf. Diuretics, 1st, 529-31. Edited by: Puschett, Jules B.; Greenberg, Arthur. Elsevier: New York, N. Y. (English) 1984. CODEN: 53NLAE. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Two different classes of diuretic drugs, (aryloxy)acetic acid (ethacrynic acid [58-54-8], tienilic acid [40180-04-9], and (-)indacrinone [56049-89-9]) natriuretic furopyridines (cicletanide [89943-82-8] and BN 50157 [91868-80-3]) stimulate K+ movements across human red cell membranes. The kinetic properties of this effect and strongly suggest that the effect is mediated by a K+ transport system with a specific binding site for some diuretic drugs. The stimulated K+ fluxes are resistant to ouabain, bumetanide and quinine, thus suggesting that they are not mediated by the Na,K-pump, Na+-K+-cotransport system or by the Ca2+-dependent K+-permeability. The intensity of stimulation of K+ fluxes is pos. correlated with the magnitude of the natriuretic effect.

The effect of cycletanide, a diuretic, on the platelet vessel wall interaction; its involvement in the arachidonic acid cascade

The effect of cycletanide, a diuretic, on the platelet vessel wall interaction; its involvement in the arachidonic acid cascade. Bourgain, R. H.; Deby, C.; Andries, R.; Garay, R.; Braquet, P. (Lab. Fysiol. Fysiopathol., Vrije Univ. Brussel, Brussels 1090, Belg.). Biochem. Pharmacol., 33(23), 3917-18 (English) 1984. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In rats, topical superfusion with cycletanide (I) [89943-82-8] (10-3M) did not affect thrombogenesis-induced by topical superfusion with ADP [58-64-0] (4 ′ 10-4M) and arachidonic acid [506-32-1] (10-4M). However, I antagonized the enhancing effect of superfused tranylcypromine [155-09-9] (2 ′ 10-3M) on ADP and arachidonic acid induced thrombogenesis. Possible mechanisms involved in the actions of I on thrombogenesis are discussed.