Detail of "90-34-6"

Reference

In vitro metabolism of the antimalarial agent primaquine by mouse liver enzymes and identification of a methemoglobin-forming metabolite

In vitro metabolism of the antimalarial agent primaquine by mouse liver enzymes and identification of a methemoglobin-forming metabolite. Strother, A.; Allahyari, R.; Buchholz, J.; Fraser, I. M.; Tilton, B. E. (Sch. Med., Loma Linda Univ., Loma Linda, CA 92350, USA). Drug Metab. Dispos., 12(1), 35-44 (English) 1984. CODEN: DMDSAI. ISSN: 0090-9556. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A metHb-forming metabolite of primaquine (I)(PQ) [90-34-6] was isolated and identified from a mouse liver microsomal system. Both O-dealkylationa nd hydroxylation of PQ to form a metabolite, 5,6-dihydroxy-8-(4-amino-1-methylbutylamino)quinoline [87321-06-0], which is highly active in forming metHb in both normal and glucose-6-phosphate dehydrogenase-deficient erythrocytes were obsd. The metabolite also actively decreases glutathione levels in glucose-6-phosphate dehydrogenase-deficient erythrocytes. The inhibitor SKF 525-A prevented metabolite formation, whereas iproniazid and CO did not inhibit metab. completely but may have resulted in formation of a different unidentified metabolite. This addnl. metabolite was identified indirectly via a blue compd. [89202-75-5] which results from extg.There are some commonly used reagents with their cas registry numbers 89202-75-5 and 90-34-6 in this article. the actual metabolite from the incubation mixt. with org. solvents under alk. conditions in the presence of light. The blue compd. was identified as a quinonimine in which the 8-amino side chain of PQ cyclizes to produce a 3 ring system. .

Effect of ascorbic acid on hemolysis induced by primaquine in vitro

Effect of ascorbic acid on hemolysis induced by primaquine in vitro. Grinberg, L. N.; Nguyen Kim Phong (Inst. 90-34-6 and 50-81-7 are also occured in this study. Med. Parazitol. Trop. Med., Moscow, USSR). Gematol. Transfuziol., 28(12), 50-2 (Russian) 1983. CODEN: GETRE8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 18 Ascorbic acid [50-81-7] (0.5-2.0 mM) inhibited primaquine [90-34-6] (3.0 mM)-induced accumulation of metHb and lysis of human erythrocytes during a 2-h incubation at 37°. The protective effect of ascorbate was greater than that of NaCHO2. NaCHO2 did not enhance the effect of ascorbate. .