Reference

Physical studies of detomidine hydrochloride, a new drug substance

Physical studies of detomidine hydrochloride, a new drug substance. Laine, Ensio; Tuominen, Virpi; Kahela, Paavo; Liponkoski, Lippo; Sjoeholm, Rainer (Dep. Phys. Sci., Univ. Turku, Turku SF-20500/50, Finland). Acta Pharm. Suec., 20(6), 451-60 (English) 1983. CODEN: APSXAS. ISSN: 0001-6675. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Solid-solid and solid-liq. transitions of detomidine-HCl (I) [90038-01-0] were studied by temp. controlled x-ray diffractometry (XRD), thermogravimetry (TG), differential scanning calorimetry (DSC) and IR and 13C NMR spectroscopy. I exists in 2 cryst. forms, an anhyd. and a hydrated form. Thermal anal. showed that the H2O was loosely bonded in the hydrous crystals. The amt. of H2O in this structure as detd. by TG suggests that it is a monohydrate. 13C NMR spectrum showed that in soln., the H2O in the hydrate is bonded via its O atom to the imidazole cation and the H2O is bonded mainly to N-3 in the imidazole ring.Except for chemicals metioned above, 90038-00-9 and 90038-01-0 are also used. .