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| CAS No.: | 9004-06-2 |
|---|---|
| Name: | Elastase |
| Molecular Structure: | |
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| Formula: | N/A |
| Molecular Weight: | 0 |
| Synonyms: | E.C.3.4.21.11; E.C. 3.4.21.36; E.C. 3.4.21.37; E.C. 3.4.24.65; E.C. 3.4.4.7;Elaszym; MMP 12; Macrophage metalloelastase; Matrix metalloprotease 12; Matrixmetalloproteinase-12; Medullasin; Metalloproteinase HME; Neutrophil Elastase;Pancreatopeptidase E; Peptidase, pancreato-, E; Proteinase, bone marrow serine;Serine elastase |
| EINECS: | 232-670-7 |
| Hazard Symbols: |
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| Safety: | Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. |
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- Total:36 Page 1 of 1 1
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Chemistry
Name: Elastase
EINECS:232-670-7
Storage temp.:−20oC
Form:lyophilized powder
History
Elastase with cas registry number of 9004-06-2 is inhibited by diisopropyl-phosphofluoridate and alkyl isocyanates (Brown and Wold 1971). Shotton and Hartley (1973) have reported on the amino acid sequence of elastase. It is a single peptide chain of 240 residues and contains 4 disulfide bridges. Sawyer et al. (1973), Shotton and Watson et al. (1970) have reported on crystal conformation and tertiary structure. Gorbunoff and Timasheff (1972) have indicated conformational behavior shifts in the alkaline range. The catalytic activity of elastase has been reported by Gold and Shalitin (1975), Kasafírek et al. (1974), Thompson (1973), Atlas and Berger (1972) , Marshall and Akgun (1971), and Schellenberger et al. (1989).
Toxicity Data With Reference
| 1. | ipr-rat LD50:78 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 7 (1976),108. | ||
| 2. | ivn-rat LD50:85 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 7 (1976),108. | ||
| 3. | orl-rat LD50:>2000mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 7 (1976),108. | ||
| 4. | ipr-mus LD50:37 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 7 (1976),108. | ||
| 5. | ivn-mus LD50:57 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 7 (1976),108. | ||
| 6. | orl-mus LD50:>2000mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 7 (1976),108. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Safty informations about Elastase (CAS NO. 9004-06-2):
Hazard Codes:B
F:3-10
Specification
Elastase with cas registry number of 9004-06-2 is also known as Neutrophil elastase ; Pancreatopeptidase E ; EC 3.4.21.36 ; EC 3.4.21.37 ; Elastase ; Elastase,leukocyte ; Elastase,neutrophil,human ; Elastase,human neutrophil . It is a White, lyophilized powder with a sltly yellowish shade. Elastase is unstable below pH 3-4. When stored as a dry powder the enzyme is stable 6-12 months. Elastase is an enzyme that can break down proteins through the cleavage of peptide bonds in the target proteins. Elastase is also frequently used to dissociate tissues which contain extensive intercellular fiber networks, because elastin can be found in highest concentrations in the elastic fibers of connective tissues. For this purpose, it is usually used with other enzymes such as collagenase , trypsin , and chymotrypsin .